Olivocerebellar projections in control and staggerer mutant mice. An autoradiographic study.

Olivocerebellar projections were studied in normal and in staggerer mutant mice by means of autoradiographic methods following [3H]leucine injections in the inferior olivary complex. In normal mice, a sagittal banding pattern of labeled climbing fibers was apparent in the contralateral cerebellar cortex, thus confirming previous observations in rodents. In staggerer mice, olivocerebellar projections also displayed a clear sagittal zonation, thus indicating that this organization may be achieved in the mutant, in spite of pronounced abnormalities of the cerebellar cortex.