Zhang Haojun, Liu Hengzhi, Zhang Lei, Di Zhenglin, Li Ming
Department of Joint Surgery, Ningbo No. 6 Hospital, Ningbo, Zhejiang, P. R. China.
Department of Orthopedic Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, P. R. China.
J Orthop Surg Res. 2025 Apr 9;20(1):353. doi: 10.1186/s13018-025-05656-9.
No studies have assessed the correlation between preoperative medial meniscus extrusion (MME) and subchondral bone marrow edema (BME) or which factor influences the outcomes after medial opening wedge high tibial osteotomy (MOWHTO). The present study aimed to determine the influence of preoperative MME and BME on outcomes after MOWHTO.
This study included 151 patients between January 2019 and January 2022 with a mean follow-up of 3.2 years. MME was classified into 2 groups according to the presence of pathologic MME (≥ 3 mm). BME was graded into 4 groups according to the lesion volume based on the MRI Osteoarthritis Knee Score (MOAKS) criteria. Clinical outcomes were assessed with the Hospital for Special Surgery (HSS) score, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and Knee Society Score (KSS).
The mean ± standard deviation preoperative MME for all patients was 3.6 ± 1.9 mm. A total of 103 patients (68.2%) had pathologic MME. MME significantly increased with increasing BME grade. Those with pathologic MME showed significantly worse outcomes in terms of the WOMAC and KSS for pain and function and HSS score than those without pathologic MME at 1 and 2 years postoperatively (all p < 0.05). A total of 122 patients (80.8%) had BME. Among the 151 patients, 29 (19.2%), 61 (40.4%), 42 (27.8%), and 19 (12.6%) were classified as having an MOAKS of 0, 1, 2, and 3, respectively, with significant differences in the preoperative WOMAC and KSS for pain and function and HSS score among these 4 groups (all P < 0.001). However, there were no significant differences in these indices at 1 or 2 years postoperatively (all P > 0.05). Only MME correlated with worse clinical outcomes in univariate (p < 0.001) and multivariate (p < 0.001) analyses.
Short-term clinical outcomes were worse for patients with preoperative MME greater than 3 mm than for those with preoperative MME less than 3 mm. There were no correlations between preoperative subchondral BME severity and postoperative outcomes.
尚无研究评估术前内侧半月板挤压(MME)与软骨下骨髓水肿(BME)之间的相关性,也未明确内侧张开楔形高位胫骨截骨术(MOWHTO)后何种因素会影响手术效果。本研究旨在确定术前MME和BME对MOWHTO术后效果的影响。
本研究纳入了2019年1月至2022年1月期间的151例患者,平均随访时间为3.2年。根据病理性MME(≥3 mm)的存在情况,将MME分为2组。根据基于MRI骨关节炎膝关节评分(MOAKS)标准的病变体积,将BME分为4组。采用特殊外科医院(HSS)评分、西安大略和麦克马斯特大学骨关节炎指数(WOMAC)以及膝关节协会评分(KSS)评估临床效果。
所有患者术前MME的平均值±标准差为3.6±1.9 mm。共有103例患者(68.2%)存在病理性MME。MME随BME分级增加而显著增加。在术后1年和2年时,病理性MME患者在WOMAC和KSS的疼痛、功能评分以及HSS评分方面,均显著低于无病理性MME的患者(所有p<0.05)。共有122例患者(80.8%)存在BME。在151例患者中,分别有29例(19.2%)、61例(40.4%)、42例(27.8%)和19例(12.6%)的MOAKS分级为0、1、2和3级,这4组患者术前WOMAC和KSS的疼痛、功能评分以及HSS评分存在显著差异(所有P<0.001)。然而,术后1年和2年时这些指标无显著差异(所有P>0.05)。单因素分析(p<0.001)和多因素分析(p<0.001)均显示,只有MME与较差的临床效果相关。
术前MME大于3 mm的患者短期临床效果比术前MME小于3 mm的患者差。术前软骨下BME严重程度与术后效果之间无相关性。