Mao Shuai-Shuai, Huang Wei, Luo Jia-Qing
Endocrine Department, Changxing People's Hospital, Huzhou, Zhejiang, China.
General Surgery, Changxing People's Hospital, Huzhou, Zhejiang, China.
Kaohsiung J Med Sci. 2025 Jul;41(7):e70024. doi: 10.1002/kjm2.70024. Epub 2025 Apr 9.
Metabolic disorders are associated with testosterone deficiency, and the cardiometabolic index (CMI) is a recently identified metabolic indicator. The relationship between male biochemical androgen deficiency (MBAD), a precursor to testosterone deficiency, and CMI remains unclear. In this cross-sectional study, we analyzed data from the National Health and Nutrition Examination Survey (NHANES) 2013-2016 to investigate the relationship between MBAD and CMI in men. This study included 1229 participants; among which, 209 participants had MBAD. Machine learning models identified that the importance of CMI on MBAD was in the top three. After adjusting for all covariates, we found a positive association between CMI and MBAD. Restricted cubic spline (RCS) curves validated this association both in age and body mass index subgroups. Trend regression showed that participants with a higher CMI tended to have a higher risk of MBAD. The positive association between CMI and MBAD persisted after multiple interpolations, validating the robustness of the results. Altogether, this study suggests that CMI exhibits a stable positive relationship with MBAD.
代谢紊乱与睾酮缺乏有关，而心脏代谢指数（CMI）是最近确定的一种代谢指标。男性生化雄激素缺乏（MBAD）作为睾酮缺乏的前驱症状，其与CMI之间的关系仍不清楚。在这项横断面研究中，我们分析了2013 - 2016年美国国家健康与营养检查调查（NHANES）的数据，以研究男性中MBAD与CMI之间的关系。本研究纳入了1229名参与者；其中，209名参与者患有MBAD。机器学习模型确定CMI对MBAD的重要性位列前三。在对所有协变量进行调整后，我们发现CMI与MBAD之间存在正相关。限制立方样条（RCS）曲线在年龄和体重指数亚组中均验证了这种相关性。趋势回归显示，CMI较高的参与者患MBAD的风险往往更高。经过多次插补后，CMI与MBAD之间的正相关仍然存在，验证了结果的稳健性。总之，本研究表明CMI与MBAD之间呈现出稳定的正相关关系。
