Study on a TCM evaluation method based on an MIP-modified MOF sensor with highly selective electrocatalytic activity-an L. perspective.

Quantitative analysis of artemisinin (ART) in decoction samples is crucial for the quality assessment of samples; however, no comprehensive solution currently exists for its rapid and sensitive quantification. This gap necessitates a novel method that accommodates the complex composition of traditional Chinese medicine samples. In this study, we developed an electrochemical sensor suitable for determining the ART content level in . By introducing MIP-MOF composites, the sensor was endowed with selectivity based on spatial and electronic structures specific to particular molecules. This sensor, which mimics the pharmacological activation process of ART, could swiftly and selectively measure ART concentrations, thereby providing a reflection of the efficacy of the samples. The sensors' limit of detection and limit of quantification were determined to be 1.738 × 10 M and 4.764 × 10 M, respectively. Methodology validation confirmed the great selectivity and accuracy of the sensor. Tests conducted across various decoction samples, including those from online and offline sources, as well as deteriorated samples, yielded results consistent with the expected ART content levels, demonstrating the sensor's potential for application in sample quality assessment.