Development of a clinical prediction model for poor treatment outcomes in the intensive phase in patients with initial treatment of pulmonary tuberculosis.

BACKGROUND

A prediction model is hereby developed to identify poor treatment outcomes during the intensive phase in patients with initial treatment of pulmonary tuberculosis (TB).

METHODS

The data of inpatients with pulmonary TB were collected from a tertiary hospital located in Southeastern China from July 2019 to December 2023. The included patients were divided into the modeling group and the validation group. The outcome indicator was based on a comparison of pulmonary CT findings before and after the two-month intensive phase of anti-TB treatment. In the modeling group, the independent risk factors of pulmonary TB patients were obtained through logistic regression analysis and then a prediction model was established. The discriminative ability (the area under the curve of the receiver operating characteristic, AUC), its calibration (GiViTI calibration chart), and its clinical applicability (decision curve analysis, DCA) were respectively evaluated. In addition, the prediction effectiveness was compared with that of the machine learning model.

RESULTS

A total of 1,625 patients were included in this study, and 343 patients had poor treatment outcomes in the intensive phase of anti-TB treatment. Logistic regression analysis identified several independent risk factors for poor treatment outcomes, including diabetes, cavities in the lungs, tracheobronchial TB, increased C-reactive protein, and decreased hemoglobin. The AUC values were 0.815 for the modeling group and 0.851 for the validation group. In the machine learning models, the AUC values of the random forest model and the integrated model were 0.821 and 0.835, respectively.

CONCLUSION

The prediction model established in this study presents good performance in predicting poor treatment outcomes during the intensive phase in patients with pulmonary TB.