Motycka S, Newth C J, Nairn J G
J Pharm Sci. 1985 Jun;74(6):643-6. doi: 10.1002/jps.2600740612.
Anion-exchange resin beads in the theophylline form were prepared and coated with paraffin or encapsulated with ethylcellulose by various methods; one of these products was subsequently coated with paraffin in order to achieve a wide range of release rates and patterns of release. The various products were subjected to rate studies, and it was found that the patterns of release and the rates could be controlled by the cross-linking of the resin and the coating procedures used. A medium and almost constant rate of release was obtained by using ethylcellulose microencapsulation, a coating of hard paraffin, or a combination of both. The amount of coating and the total amount of drug released was also determined.
制备了呈茶碱形式的阴离子交换树脂珠，并通过各种方法用石蜡进行包衣或用乙基纤维素进行包封；随后对其中一种产品用石蜡进行包衣，以实现广泛的释放速率和释放模式。对各种产品进行了速率研究，发现释放模式和速率可通过树脂的交联和所采用的包衣程序来控制。通过使用乙基纤维素微囊化、硬石蜡包衣或两者结合，可获得中等且几乎恒定的释放速率。还测定了包衣量和药物释放总量。
