Motycka S, Nairn J G
J Pharm Sci. 1979 Feb;68(2):211-5. doi: 10.1002/jps.2600680223.
Ion-exchange resin beads in the benzoate form were coated by several microencapsulation techniques to alter and improve characteristics, especially the control of drug release, of this type of drug delivery system. The most successful techniques included polymer-polymer interaction, temperature change, and nonsolvent addition. The microencapsulated beads then were studied with respect to the release rate of the organic anion to determine the effects of microencapsulation. The release rate of the organic anion could be controlled over a wide range, depending on the encapsulating material characteristics. Factors affecting the extent and rate of release as result of microencapsulation are discussed.
将苯甲酸盐形式的离子交换树脂珠粒通过几种微囊化技术进行包衣，以改变和改善这类药物递送系统的特性，尤其是药物释放的控制。最成功的技术包括聚合物-聚合物相互作用、温度变化和添加非溶剂。然后针对有机阴离子的释放速率对微囊化珠粒进行研究，以确定微囊化的效果。根据包封材料的特性，有机阴离子的释放速率可以在很宽的范围内得到控制。本文讨论了微囊化对释放程度和速率产生影响的因素。
