Motycka S, Nairn J G
J Pharm Sci. 1978 Apr;67(4):500-3. doi: 10.1002/jps.2600670416.
Ion-exchange resin beads were coated with various waxes to improve and control their release. The in vitro release rates of benzoate ions from the coated-resin beads were then investigated using a rotating sieve basket technique. The dramatic differences in release rates observed with the different waxes can be discussed in terms of the wax to resin ration and the solubility characteristics of the waxes. The initial release rates can be expressed in terms of a mathematical expression previously reported for the diffusion of ions in ion-exchange resins, thereby aiding in the elucidation of the effect of the waxes on release.
离子交换树脂珠粒用各种蜡进行包衣，以改善并控制其释放。然后采用旋转筛篮技术研究了包衣树脂珠粒中苯甲酸根离子的体外释放速率。观察到不同蜡的释放速率存在显著差异，这可以根据蜡与树脂的比例以及蜡的溶解特性来讨论。初始释放速率可以用先前报道的离子在离子交换树脂中扩散的数学表达式来表示，从而有助于阐明蜡对释放的影响。
