辣椒素脱敏大鼠的下丘脑温度敏感性
Hypothalamic thermosensitivity in capsaicin-desensitized rats.
作者信息
Cormarèche-Leydier M, Shimada S G, Stitt J T
出版信息
J Physiol. 1985 Jun;363:227-36. doi: 10.1113/jphysiol.1985.sp015706.
Abstract
In rats, we tested the hypothesis that capsaicin desensitization reduces hypothalamic warm thermosensitivity. We locally heated and cooled the hypothalamus using water-perfused thermodes while observing thermoregulatory variables. In untreated rats, a small dose of capsaicin had profound effects on thermoregulation. However, desensitizing rats to capsaicin had no effect on hypothalamic thermosensitivity for metabolic rate or changes in body temperature due to displacements of hypothalamic temperature. Contrary to current opinion, we conclude that capsaicin desensitization does not alter hypothalamic thermosensitivity to warm or cold.
摘要
在大鼠中，我们检验了辣椒素脱敏会降低下丘脑热敏感性这一假说。我们使用水灌注式热电极对下丘脑进行局部加热和冷却，同时观察体温调节变量。在未处理的大鼠中，小剂量辣椒素对体温调节有显著影响。然而，使大鼠对辣椒素脱敏对下丘脑热敏感性没有影响，即对代谢率或因下丘脑温度变化引起的体温变化没有影响。与当前观点相反，我们得出结论，辣椒素脱敏不会改变下丘脑对热或冷的热敏感性。
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