Dessenne Clara, Mariller Christophe, Vidal Olivier, Huvent Isabelle, Guerardel Yann, Elass-Rochard Elisabeth, Rossez Yannick
Université Lille, CNRS, UMR 8576-UGSF-Unité de Glycobiologie Structurale et Fonctionnelle, Lille, France.
Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan.
BBA Adv. 2025 Mar 14;7:100156. doi: 10.1016/j.bbadva.2025.100156. eCollection 2025.
Bacterial adhesins play a central role in host-pathogen interactions, with many specifically targeting glycans to mediate bacterial colonization, influence infection dynamics, and evade host immune responses. In this review, we focus on bacterial pathogens identified by the World Health Organization as critical threats to public health and in urgent need of new treatments. We summarize glycoconjugate targets identified in the literature across 19 bacterial genera and species. This comprehensive review provides a foundation for the development of innovative therapeutic strategies to effectively combat these pathogens.
细菌黏附素在宿主与病原体的相互作用中起着核心作用，许多黏附素专门靶向聚糖以介导细菌定植、影响感染动态并逃避宿主免疫反应。在本综述中，我们聚焦于世界卫生组织确定为对公众健康构成重大威胁且急需新治疗方法的细菌病原体。我们总结了文献中确定的19个细菌属和种的糖缀合物靶点。这一全面综述为开发有效对抗这些病原体的创新治疗策略奠定了基础。
