Department of Biochemistry, Central University of Rajasthan, Ajmer 305817, India.
Department of Biochemistry, Central University of Rajasthan, Ajmer 305817, India.
Int J Biol Macromol. 2018 Jun;112:54-64. doi: 10.1016/j.ijbiomac.2018.01.151. Epub 2018 Feb 26.
Host-pathogen interaction is one of the most important areas of study to understand the adhesion of the pathogen to the host organisms. To adhere on the host cell surface, bacteria assemble the diverse adhesive structures on its surface, which play a foremost role in targeting to the host cell. We have highlighted different bacterial adhesins which are either protein mediated or glycan mediated. The present article listed examples of different bacterial adhesin proteins involved in the interactions with their host, types and subtypes of the fimbriae and non-fimbriae bacterial adhesins. Different bacterial surface adhesin subunits interact with host via different host surface biomolecules. We have also discussed the interactome of some of the pathogens with their host. Therefore, the present study will help researchers to have a detailed understanding of different interacting bacterial adhesins and henceforth, develop new therapies, adhesin specific antibodies and vaccines, which can effectively control pathogenicity of the pathogens.
宿主-病原体相互作用是理解病原体与宿主生物粘附的最重要研究领域之一。为了粘附在宿主细胞表面，细菌在其表面组装各种不同的粘附结构，这些结构在靶向宿主细胞方面起着最重要的作用。我们已经强调了不同的细菌黏附素，这些黏附素要么是由蛋白质介导的，要么是由聚糖介导的。本文列出了参与与宿主相互作用的不同细菌黏附蛋白的例子，包括菌毛和非菌毛细菌黏附素的类型和亚型。不同的细菌表面黏附亚基通过不同的宿主表面生物分子与宿主相互作用。我们还讨论了一些病原体与其宿主的相互作用组。因此，本研究将帮助研究人员深入了解不同的相互作用的细菌黏附素，并由此开发出能够有效控制病原体致病性的新疗法、黏附素特异性抗体和疫苗。
