Cadigan R Jean, Waltz Margaret, Conley John M, Major Rami M, Branch Elizabeth K, Juengst Eric T, Flatt Michael A
Department of Social Medicine, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA.
School of Law, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA.
New Genet Soc. 2024;43(1). doi: 10.1080/14636778.2024.2404061. Epub 2024 Sep 20.
Heritable human genome editing has garnered significant attention in scholarly and lay media, yet questions remain about whether, when, and how heritable genome editing ought to proceed. Drawing on interviews with scientists who use genome editing in their research and professionals engaged in human genome editing governance efforts, we examine their views on the permissibility of heritable genome editing and the governance strategies they see as necessary and realistic. For both issues, we found divergent views from respondents. We place the views of these scientists and governance professionals within the context of the larger bioethical discussion of heritable genome editing governance, along a continuum of hard to soft approaches. These respondents' views highlight the challenges of various hard forms of governance and the potential virtues of soft governance approaches.
可遗传的人类基因组编辑在学术和大众媒体中都引起了广泛关注,但关于可遗传基因组编辑是否应该进行、何时进行以及如何进行,仍然存在诸多问题。通过对在研究中使用基因组编辑的科学家以及参与人类基因组编辑治理工作的专业人员进行访谈,我们考察了他们对可遗传基因组编辑可允许性的看法以及他们认为必要且现实的治理策略。对于这两个问题,我们发现受访者的观点存在分歧。我们将这些科学家和治理专业人员的观点置于关于可遗传基因组编辑治理的更大生物伦理讨论背景下,沿着从强硬到温和的方法连续统进行分析。这些受访者的观点凸显了各种强硬治理形式的挑战以及温和治理方法的潜在优点。