Meng Tong, Feng Rui, Zhu Yunlong, Luo Jincheng, Zhang Andong, Liu Yi, Chen Jing, Yang Cheng
Department of Urology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, Anhui, China.
Institute of Urology, Anhui Medical University, Hefei, Anhui, China.
Clin Exp Immunol. 2025 Jan 21;219(1). doi: 10.1093/cei/uxaf022.
Chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS) are diagnosed in patients with various pelvic or genitourinary symptoms irrespective of the presence of a tender prostate. The etiology of chronic nonbacterial prostatitis remains unclear. Current treatments such as alpha-blockers, neuroleptics, anti-inflammatory, medications, and physical therapy, are often unsatisfactory. New treatments, as well as an improved knowledge of the underlying CP/CPPS pathogenesis, are thus needed. Sulforaphane (SFN), an isothiocyanate found in large quantities in Brassica species, has shown therapeutic effects on inflammation and cancer, and can protect against DNA damage and modulate the cell cycle to control apoptosis, angiogenesis, and metastasis. At the molecular level, SFN modulates cell homeostasis by activating the transcription factor Nrf2. However, its effect on CP/CPPS is not clear. Here, SFN was found to alleviate inflammation by suppressing NLRP3 inflammasomes via the Nrf2/HO-1 axis, as demonstrated in both animal and cellular analyses.
慢性前列腺炎和慢性盆腔疼痛综合征（CP/CPPS）是在出现各种盆腔或泌尿生殖系统症状的患者中诊断出来的，无论前列腺是否有压痛。慢性非细菌性前列腺炎的病因仍不清楚。目前的治疗方法，如α受体阻滞剂、抗精神病药物、抗炎药物和物理治疗，往往不尽人意。因此，需要新的治疗方法以及对CP/CPPS潜在发病机制的更深入了解。萝卜硫素（SFN）是十字花科植物中大量存在的一种异硫氰酸盐，已显示出对炎症和癌症的治疗作用，并且可以防止DNA损伤并调节细胞周期以控制细胞凋亡、血管生成和转移。在分子水平上，SFN通过激活转录因子Nrf2来调节细胞内稳态。然而，其对CP/CPPS的影响尚不清楚。在此，动物和细胞分析均表明，SFN通过Nrf2/HO-1轴抑制NLRP3炎性小体来减轻炎症。
