Woodtli Vivienne, Sachs David, Stracuzzi Alberto, Robmann Serjosha, Biedermann Thomas, Böttcher-Haberzeth Sophie, Thumm Bettina
Pediatric Burn Center, Children's Skin Center, Department of Surgery, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.
Department of Surgery, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.
Methods Mol Biol. 2025;2922:297-304. doi: 10.1007/978-1-0716-4510-9_23.
Optimizing skin tissue engineering necessitates the precise and objective assessment of scar quality. One approach to achieve this evaluation is through the measurement of the skin's or skin substitutes specific mechanical properties, such as elasticity and firmness. This chapter introduces a measurement protocol for clinical assessment of these properties using a suction device, known as the Nimble. The Nimble device quantitatively evaluates the mechanical characteristics of the skin by applying controlled negative pressure to elevate the skin to a predetermined level, thereby allowing for the measurement of skin elasticity and other related parameters. In this chapter, we provide a detailed description of the Nimble's operation, including the step-by-step process for conducting measurements, and offer guidance on the interpretation of the collected data to assess scar quality effectively.
优化皮肤组织工程需要对瘢痕质量进行精确且客观的评估。实现这种评估的一种方法是通过测量皮肤或皮肤替代物的特定力学性能，如弹性和硬度。本章介绍一种使用名为Nimble的抽吸装置对这些性能进行临床评估的测量方案。Nimble装置通过施加可控的负压将皮肤提升到预定水平，从而定量评估皮肤的力学特性，进而能够测量皮肤弹性和其他相关参数。在本章中，我们详细描述了Nimble的操作，包括进行测量的逐步过程，并就如何解释收集到的数据以有效评估瘢痕质量提供指导。
