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儿童突发性感音神经性听力损失的预后因素及临床特征:一项回顾性分析

Prognostic Factors and Clinical Characteristics in Pediatric Sudden Sensorineural Hearing Loss: A Retrospective Analysis.

作者信息

Zhao Ranshi, Huang Maoling, Zhong Cheng

机构信息

Department of Otolaryngology Southwest Hospital, Army Medical University Chongqing China.

出版信息

Laryngoscope Investig Otolaryngol. 2025 Apr 10;10(2):e70112. doi: 10.1002/lio2.70112. eCollection 2025 Apr.

Abstract

OBJECTIVE

To investigate the clinical characteristics and prognostic factors influencing treatment outcomes in pediatric sudden sensorineural hearing loss (PSSNHL).

METHODS

A retrospective analysis was conducted on 63 children (64 ears) diagnosed with PSSNHL from January 2013 to December 2023. All patients received either systemic or intra-tympanic steroid therapy. Data on age, tinnitus presence, audiogram types, and initial hearing thresholds were analyzed using SPSS 25.0. Univariate and multivariate logistic regressions were performed to identify significant prognostic factors.

RESULTS

The mean age was 16 years (interquartile range:14-17 years). Median time from symptom onset to treatment was 7 days (interquartile range: 4-13 days). Tinnitus was present in 85.7% of cases. Post-treatment hearing thresholds improved from 84.52 ± 3.29 dB HL to 64.17 ± 4.48 dB HL ( < 0.001). The overall therapeutic efficacy rate was 48.4%. Multivariate analysis identified time from onset to treatment (OR = 0.923; 95% CI: 0.789-0.997;  < 0.01) and initial hearing threshold (OR = 0.939; 95% CI: 0.869-0.981;  < 0.05) as independent prognostic factors.

CONCLUSIONS

Early intervention and lower initial hearing thresholds are associated with a better prognosis in PSSNHL. Prompt treatment significantly improves outcomes, highlighting the importance of early diagnosis and intervention.

LEVEL OF EVIDENCE

Level 4.

摘要

目的

探讨小儿突发性感音神经性听力损失(PSSNHL)的临床特征及影响治疗效果的预后因素。

方法

对2013年1月至2023年12月诊断为PSSNHL的63例儿童(64耳)进行回顾性分析。所有患者均接受全身或鼓室内类固醇治疗。使用SPSS 25.0分析年龄、耳鸣情况、听力图类型和初始听力阈值等数据。进行单因素和多因素逻辑回归分析以确定显著的预后因素。

结果

平均年龄为16岁(四分位间距:14 - 17岁)。从症状出现到治疗的中位时间为7天(四分位间距:4 - 13天)。85.7%的病例存在耳鸣。治疗后听力阈值从84.52±3.29 dB HL改善至64.17±4.48 dB HL(P<0.001)。总体治疗有效率为48.4%。多因素分析确定从发病到治疗的时间(OR = 0.923;95% CI:0.789 - 0.997;P<0.01)和初始听力阈值(OR = 0.939;95% CI:0.869 - 0.981;P<0.05)为独立预后因素。

结论

早期干预和较低的初始听力阈值与PSSNHL的较好预后相关。及时治疗可显著改善预后,凸显早期诊断和干预的重要性。

证据水平

4级。

相似文献

4
Clinical Practice Guideline: Sudden Hearing Loss (Update).临床实践指南:突发性聋(更新)。
Otolaryngol Head Neck Surg. 2019 Aug;161(1_suppl):S1-S45. doi: 10.1177/0194599819859885.

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