Ganz Alexander S, Greeley Brooke, Riggen James, Riggen Aundria
Department of Biology, Southern Methodist University, Dallas, NC, United States.
Department of Biology, Indiana University, Bloomington, IN, United States.
Front Med (Lausanne). 2025 Mar 27;12:1572261. doi: 10.3389/fmed.2025.1572261. eCollection 2025.
This open-label study evaluated the effects of a novel fiber supplement product, Relievance, on bowel movement regularity and symptoms of bloating and gas in 20 consecutive patients. The product is a commercially available combination of 8 natural fibers and the recommended dosage is approximately 6 grams per serving.
Participants, presenting with chronic bothersome gastrointestinal symptoms of bloating, gas or bowel irregularity were recruited from an outpatient primary care practice for the study. Participants consumed 6 g of the fiber blend (one heaping teaspoon), one to three times per day, over 6 weeks, and kept diaries on symptoms and number of bowel movements per week. Symptoms were assessed via a 6-point analog scale at baseline and at 6 weeks. Primary endpoints included changes in bowel movement frequency and symptom severity related to gas and bloating.
At baseline, participants averaged 1.7 bowel movements per week, which significantly increased to 3.2 per week by the study's conclusion. Symptom severity scores for bloating and gas also improved significantly, decreasing from 3.0 at baseline to 1.5 after 6 weeks. These results demonstrated statistically significant improvements in both bowel regularity and symptom relief. No significant adverse events were reported during the study, highlighting the product's safety profile.
This small, non-randomized prospective trial suggests that Relievance, a proprietary blend of eight different fibers, may effectively enhance bowel movement frequency and alleviate symptoms of bloating and gas. Further randomized controlled trials are warranted to confirm these findings and explore broader applications.
这项开放标签研究评估了一种新型纤维补充剂产品Relievance对20名连续患者排便规律以及腹胀和气体症状的影响。该产品是8种天然纤维的商业组合，推荐剂量约为每份6克。
从门诊初级保健机构招募有慢性腹胀、气体或排便不规律等令人困扰的胃肠道症状的参与者进行研究。参与者在6周内每天服用1至3次6克纤维混合物（满满一茶匙），并记录症状和每周排便次数。在基线和6周时通过6点模拟量表评估症状。主要终点包括排便频率的变化以及与气体和腹胀相关的症状严重程度。
在基线时，参与者平均每周排便1.7次，到研究结束时显著增加到每周3.2次。腹胀和气体的症状严重程度评分也显著改善，从基线时的3.0降至6周后的1.5。这些结果表明排便规律和症状缓解方面均有统计学上的显著改善。研究期间未报告重大不良事件，突出了该产品的安全性。
这项小型、非随机前瞻性试验表明，Relievance（一种由八种不同纤维组成的专利混合物）可能有效提高排便频率并缓解腹胀和气体症状。有必要进行进一步的随机对照试验来证实这些发现并探索更广泛的应用。
