Neshcheret A P
Kardiologiia. 1985 Apr;25(4):94-8.
The effect of hyperglycemia on adrenergic response of the heart and coronary vessels was examined, using an alloxan diabetes model, in an experimental study involving catheterization, extracorporal perfusion and coronary arterial resistance measurement in dogs with intact thoracic cavities. Experimental diabetes mellitus was shown to be associated with enhanced positively chronotropic--and weakened negatively chrono- and inotropic--cardiac response to catecholamines introduced into the perfusion flow. Adrenergic reactive dilatation of coronary vessels was first enhanced, and later weakened, as glycemia progressed. It is assumed that a disturbance of hormonal interrelations due to insulin deficiency may play a role in the mechanism of changed adrenergic response of the heart and coronary vessels in experimental diabetes mellitus.
在一项涉及完整胸腔犬的导管插入术、体外灌注和冠状动脉阻力测量的实验研究中，使用四氧嘧啶糖尿病模型，研究了高血糖对心脏和冠状动脉肾上腺素能反应的影响。实验性糖尿病表现为对灌注液中注入的儿茶酚胺的正性变时性心脏反应增强，而负性变时性和变力性心脏反应减弱。随着血糖升高，冠状动脉的肾上腺素能反应性扩张首先增强，随后减弱。据推测，胰岛素缺乏导致的激素相互关系紊乱可能在实验性糖尿病中心脏和冠状动脉肾上腺素能反应改变的机制中起作用。
