血浆置换治疗甲状腺毒症性肌病吞咽困难

Thyrotoxicosis-Induced Myopathic Dysphagia Treated With Plasmapheresis.

作者信息

Andrews Michael B, Stevenson Mary, Puri Puneet

机构信息

Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA.

Division of Endocrinology, Diabetes and Metabolism, Virginia Commonwealth University, Richmond, VA.

出版信息

ACG Case Rep J. 2025 Apr 10;12(4):e01668. doi: 10.14309/crj.0000000000001668. eCollection 2025 Apr.

DOI:10.14309/crj.0000000000001668

PMID:40212858

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11984784/

Abstract

Thyrotoxicosis is a rare cause of dysphagia. Plasmapheresis is a reserved treatment option for cases of thyrotoxicosis with severe symptoms refractory to or with contraindications to standard medical therapy. This is a case of a woman with newly diagnosed Graves' disease and rapidly reversible severe thyrotoxicosis-induced myopathic dysphagia successfully treated with plasmapheresis after failed treatment attempts with standard medical therapy. Symptoms improved after 1 treatment session followed by improvement in thyroid biochemical markers.

摘要

甲状腺毒症是吞咽困难的罕见病因。血浆置换是甲状腺毒症伴有严重症状且对标准药物治疗无效或有禁忌证时保留的治疗选择。本文报告一例新诊断为格雷夫斯病且迅速可逆的严重甲状腺毒症所致肌病性吞咽困难的女性患者，在标准药物治疗失败后，经血浆置换成功治愈。一次治疗后症状改善，随后甲状腺生化指标也有所改善。