Argutinskaia S V, Maĭstrenko V F, Salganik R I
Probl Endokrinol (Mosk). 1979 Sep-Oct;25(5):41-5.
Restoration of tyrosinamine transferase (TAT) with cortisol in the rat hepatocytes after the cessation of prolonged (for many days) administration of this hormone was investigated. The effect of the liver regeneration and insulin administration on this process was also studied. In single cortisol administration the TAT activity rose 5-fold; the induction response decreased after 21 days of daily administration. The TAT induction in response to cortisol administration was restored completely only on the 25th--30th day after the cessation of this hormone injection. A three-day insulin administration led to the restoration of TAT induction in response to cortisol administration. The process of the liver regeneration during the first 24 hours after partial hepatectomy induced TAT in the cells of both control animals and those given cortisol for prolonged periods; besides, it aided restoration of the induction response to cortisol administration.
研究了在长时间（持续多日）给予大鼠肝细胞皮质醇后停止给药时，皮质醇对酪氨酸胺转移酶（TAT）的恢复作用。还研究了肝脏再生和胰岛素给药对该过程的影响。单次给予皮质醇时，TAT活性升高了5倍；每日给药21天后诱导反应降低。仅在停止注射该激素后的第25至30天，对皮质醇给药的TAT诱导才完全恢复。连续三天给予胰岛素可使对皮质醇给药的TAT诱导恢复。部分肝切除术后最初24小时内的肝脏再生过程在对照动物和长期给予皮质醇的动物的细胞中均诱导了TAT；此外，它有助于恢复对皮质醇给药的诱导反应。
