Yuan Hongwang, Hua Zhanyan, Zhang Hua, Xu Dingwen
Department of Clinic, School of Medicine, Yangzhou Polytechnic University, Yangzhou, 225009, Jiangsu, China.
Sterilization Supply Center, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, 210000, Jiangsu, China.
Discov Oncol. 2025 Aug 18;16(1):1572. doi: 10.1007/s12672-025-03332-2.
Ovarian cancer ranks first among malignant tumors in the female reproductive system. Ferroptosis plays a crucial role in the occurrence, development, and treatment of ovarian cancer. However, research focusing on the bibliometric analysis of ferroptosis in ovarian cancer remains scarce. This study employs bibliometric methods to analyze research trends related to ferroptosis in the field of ovarian cancer, providing direction for scholars and clinical practitioners.
Articles regarding ferroptosis and ovarian cancer were retrieved from the Web of Science Core Database up to November 6, 2024. After rigorous screening, bibliometric analysis utilized VOSviewer and CiteSpace, while CoreMine facilitated text mining in relation to drugs and genes significantly associated with ovarian cancer and ferroptosis.
The publication volume of articles on ferroptosis and ovarian cancer has shown a yearly increase, significantly surging after 2022. The three countries with the highest publication outputs are China, the United States, and Japan. The top ten institutions with the most publications are all from China. The ten most frequently mentioned keywords are ferroptosis, ovarian cancer, cell death, apoptosis, expression, death, iron, resistance, metabolism, and cells. Text mining reveals that cisplatin, along with the genes/proteins SLC7A11 and GPX4, significantly correlates with both ovarian cancer and ferroptosis.
Our article uses bibliometric methods to reveal publication trends, national distributions, regional collaborations, and recent research hotspots related to the correlation between ferroptosis and ovarian cancer. This study provides objective data as a reference for scientific research and clinical work concerning ferroptosis and ovarian cancer.
卵巢癌在女性生殖系统恶性肿瘤中位居首位。铁死亡在卵巢癌的发生、发展及治疗中起着关键作用。然而，聚焦于卵巢癌中铁死亡的文献计量分析的研究仍较为匮乏。本研究采用文献计量方法分析卵巢癌领域中铁死亡的研究趋势，为学者和临床医生提供方向。
截至2024年11月6日，从科学网核心数据库检索有关铁死亡和卵巢癌的文章。经过严格筛选后，利用VOSviewer和CiteSpace进行文献计量分析，而CoreMine则助力对与卵巢癌和铁死亡显著相关的药物和基因进行文本挖掘。
关于铁死亡和卵巢癌的文章发表量呈逐年上升趋势，在2022年后显著激增。发表量最高的三个国家是中国、美国和日本。发表量最多的前十所机构均来自中国。提及频率最高的十个关键词是铁死亡、卵巢癌、细胞死亡、凋亡、表达、死亡、铁、耐药性、代谢和细胞。文本挖掘显示，顺铂以及基因/蛋白质溶质载体家族7成员11（SLC7A11）和谷胱甘肽过氧化物酶4（GPX4）与卵巢癌和铁死亡均显著相关。
我们的文章运用文献计量方法揭示了与铁死亡和卵巢癌相关性有关的发表趋势、国家分布、区域合作及近期研究热点。本研究提供客观数据，为有关铁死亡和卵巢癌的科研及临床工作提供参考。
