Ferroptosis and ovarian cancer: a bibliometric study and visualization analysis.

BACKGROUND

Ovarian cancer ranks first among malignant tumors in the female reproductive system. Ferroptosis plays a crucial role in the occurrence, development, and treatment of ovarian cancer. However, research focusing on the bibliometric analysis of ferroptosis in ovarian cancer remains scarce. This study employs bibliometric methods to analyze research trends related to ferroptosis in the field of ovarian cancer, providing direction for scholars and clinical practitioners.

METHODS

Articles regarding ferroptosis and ovarian cancer were retrieved from the Web of Science Core Database up to November 6, 2024. After rigorous screening, bibliometric analysis utilized VOSviewer and CiteSpace, while CoreMine facilitated text mining in relation to drugs and genes significantly associated with ovarian cancer and ferroptosis.

RESULTS

The publication volume of articles on ferroptosis and ovarian cancer has shown a yearly increase, significantly surging after 2022. The three countries with the highest publication outputs are China, the United States, and Japan. The top ten institutions with the most publications are all from China. The ten most frequently mentioned keywords are ferroptosis, ovarian cancer, cell death, apoptosis, expression, death, iron, resistance, metabolism, and cells. Text mining reveals that cisplatin, along with the genes/proteins SLC7A11 and GPX4, significantly correlates with both ovarian cancer and ferroptosis.

CONCLUSIONS

Our article uses bibliometric methods to reveal publication trends, national distributions, regional collaborations, and recent research hotspots related to the correlation between ferroptosis and ovarian cancer. This study provides objective data as a reference for scientific research and clinical work concerning ferroptosis and ovarian cancer.