Seene T, Alev K
J Steroid Biochem. 1985 Jun;22(6):767-71. doi: 10.1016/0022-4731(85)90284-5.
The catabolic action of glucocorticoids on the molecular level of the two main muscular proteins, myosin and actin, was found to depend on the type of muscle fibres. The synthesis rate of actin and myosin heavy chain was decreased in all types of muscle fibres, and in myosin light chain only in the slow-twitch red fibres. The turnover rate of actin and myosin heavy chain was also found decreased in all types of muscle fibres. The myosin light chains turned over more rapidly in dexamethasone-treated than in the control rats in all types of muscle fibres except in the case of the slow-twitch red ones as was shown by single and double isotope methods. Dexamethasone treatment enhanced the urinary 3-methylhistidine excretion in rats by 60%.
糖皮质激素对两种主要肌肉蛋白——肌球蛋白和肌动蛋白——分子水平的分解代谢作用被发现取决于肌纤维的类型。肌动蛋白和肌球蛋白重链的合成速率在所有类型的肌纤维中均降低，而肌球蛋白轻链仅在慢肌红纤维中降低。肌动蛋白和肌球蛋白重链的周转率在所有类型的肌纤维中也被发现降低。单同位素和双同位素方法显示，除慢肌红纤维外，在所有类型的肌纤维中，地塞米松处理的大鼠肌球蛋白轻链的周转速度比对照大鼠更快。地塞米松处理使大鼠尿中3-甲基组氨酸排泄增加60%。
