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通过尿中Nτ-甲基组氨酸排泄量估算的肌球蛋白和肌动蛋白的分解代谢率：食物摄入量受限条件下膳食蛋白质水平对分解代谢率的影响。

Fractional catabolic rates of myosin and actin estimated by urinary excretion of Ntau-methylhistidine: the effect of dietary protein level on catabolic rates under conditions of restricted food intake.

作者信息

Nishizawa N, Shimbo M, Hareyama S, Funabiki R

出版信息

Br J Nutr. 1977 May;37(3):345-53. doi: 10.1079/bjn19770038.

DOI:10.1079/bjn19770038
PMID:861187
Abstract
  1. Critical studies on the distribution of Ntau-methylhistidine (3-methylhistidine; Me-His) among organs and tissues in adult rats are reported. Adult rats contained 46-5+/-3-6 mg Me-His/kg body-weight. Almost 90% of the Me-His in the body was recovered from skeletal muscle. These results support the hypothesis that fractional catabolic rates of myosin and actin in skeletal muscle can be estimated by measuring urinary excretion of Me-His. 2. Dietary protein level did not affect the total amount of Me-His in the body. However, urinary excretion of Me-His increased as dietary protein intake was increased. 3. From these results it was concluded that fractional catabolic rates of myosin and actin increase as dietary protein intake increases.
摘要
  1. 报道了对成年大鼠各器官和组织中Nτ-甲基组氨酸（3-甲基组氨酸；Me-His）分布的批判性研究。成年大鼠体内Me-His含量为46.5±3.6毫克/千克体重。体内近90%的Me-His可从骨骼肌中回收。这些结果支持了这样一种假设，即通过测量尿中Me-His的排泄量可以估算骨骼肌中肌球蛋白和肌动蛋白的分解代谢率。2. 饮食蛋白质水平不影响体内Me-His的总量。然而，随着饮食蛋白质摄入量的增加，尿中Me-His的排泄量增加。3. 从这些结果得出结论，随着饮食蛋白质摄入量的增加，肌球蛋白和肌动蛋白的分解代谢率增加。

相似文献

1
Fractional catabolic rates of myosin and actin estimated by urinary excretion of Ntau-methylhistidine: the effect of dietary protein level on catabolic rates under conditions of restricted food intake.通过尿中Nτ-甲基组氨酸排泄量估算的肌球蛋白和肌动蛋白的分解代谢率：食物摄入量受限条件下膳食蛋白质水平对分解代谢率的影响。
Br J Nutr. 1977 May;37(3):345-53. doi: 10.1079/bjn19770038.
2
Fractional flux rates of Nt-methylhistidine in skin and gastrointestine: the contribution of these tissues to urinary excretion of Nt-methylhistidine in the rat.
Br J Nutr. 1977 Jul;38(1):149-51. doi: 10.1079/bjn19770072.
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Quantitative determination of urinary N-tau-methylhistidine output as an index of myofibrillar protein degradation.定量测定尿中N-τ-甲基组氨酸排出量作为肌原纤维蛋白降解的指标。
J Biochem. 1981 Apr;89(4):1155-61.
4
Effects of dietary protein level on catabolic rates of myosin and actin the rat revealed by urinary excretion of 3-methylhistidine.膳食蛋白质水平对大鼠肌球蛋白和肌动蛋白分解代谢率的影响：通过3-甲基组氨酸尿排泄量揭示
J Nutr Sci Vitaminol (Tokyo). 1975;21(5):383-5. doi: 10.3177/jnsv.21.383.
5
Quantitative aspect of the myofibrillar protein turnover in transient state on dietary protein depletion and repletion revealed by urinary excretion of N7-methylhistid;ne.通过尿中N7-甲基组氨酸排泄量揭示的膳食蛋白质缺乏和补充时肌原纤维蛋白周转瞬态的定量方面。
Biochim Biophys Acta. 1976 Nov 18;451(1):143-50. doi: 10.1016/0304-4165(76)90266-x.
6
Dietary protein intake and 3-methylhistidine excretion in the rat.大鼠的膳食蛋白质摄入量与3-甲基组氨酸排泄量
Br J Nutr. 1980 Nov;44(3):381-90. doi: 10.1079/bjn19800053.
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Ntau-methylhistidine (3-methylhistidine) and muscle protein turnover: an overview.Nτ-甲基组氨酸（3-甲基组氨酸）与肌肉蛋白质周转：概述
Fed Proc. 1978 Jul;37(9):2291-300.
8
Myofibrillar protein turnover and urinary N-tau-methylhistidine output. Response to dietary supply of protein and energy.肌原纤维蛋白周转与尿N-τ-甲基组氨酸排出量。对蛋白质和能量膳食供应的反应。
Biochem J. 1975 Dec;152(3):503-10. doi: 10.1042/bj1520503.
9
Modification of glucocorticoid-induced changes in myofibrillar protein turnover in rats by protein and energy deficiency as assessed by urinary excretion of Ntau-methylhistidine.通过Nτ-甲基组氨酸的尿排泄评估蛋白质和能量缺乏对糖皮质激素诱导的大鼠肌原纤维蛋白周转变化的影响。
Br J Nutr. 1984 May;51(3):323-37. doi: 10.1079/bjn19840039.
10
The Ntau-methylhistidine content of myosin in stimulated and cross-reinnervated skeletal muscles of the rabbit.
FEBS Lett. 1975 Sep 1;57(1):107-11. doi: 10.1016/0014-5793(75)80163-3.

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BMC Cardiovasc Disord. 2020 May 15;20(1):228. doi: 10.1186/s12872-020-01514-0.
2
Quantitative importance of non-skeletal-muscle sources of N tau-methylhistidine in urine.尿液中N-τ-甲基组氨酸非骨骼肌来源的定量重要性。
Biochem J. 1980 Jul 15;190(1):225-8. doi: 10.1042/bj1900225.
3
Reappraisal of the quantitative importance of non-skeletal-muscle source of N tau-methylhistidine in urine.
对尿液中N-τ-甲基组氨酸非骨骼肌来源的定量重要性的重新评估。
Biochem J. 1981 Mar 15;194(3):1011-4. doi: 10.1042/bj1941011.
4
3-Methylhistidine turnover in the whole body, and the contribution of skeletal muscle and intestine to urinary 3-methylhistidine excretion in the adult rat.成年大鼠全身的3-甲基组氨酸周转率以及骨骼肌和肠道对尿中3-甲基组氨酸排泄的贡献。
Biochem J. 1983 Aug 15;214(2):607-15. doi: 10.1042/bj2140607.
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Variation among chicken stocks in the fractional rates of muscle protein synthesis and degradation.不同鸡种肌肉蛋白质合成与降解分数率的差异。
Biochem Genet. 1984 Aug;22(7-8):687-700. doi: 10.1007/BF00485853.
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Genetic studies on the muscle protein turnover rate of coturnix quail.鹌鹑肌肉蛋白质周转率的遗传学研究。
Biochem Genet. 1986 Apr;24(3-4):207-16. doi: 10.1007/BF00502789.