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BMC Cancer. 2024 Mar 29;24(1):397. doi: 10.1186/s12885-024-11939-x.
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J Clin Oncol. 2024 Jun 20;42(18):2207-2218. doi: 10.1200/JCO.23.01648. Epub 2024 Mar 14.
4
Leveraging transcriptomics for precision diagnosis: Lessons learned from cancer and sepsis.利用转录组学进行精准诊断：从癌症和脓毒症中吸取的经验教训。
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进入Ⅲ期结肠癌个性化风险评估的多维预后时代。

Entering the Era of Multidimensional Prognostication for Personalized Risk Assessment in Stage III Colon Cancer.

作者信息

Rousseau Benoit, Cercek Andrea

机构信息

Memorial Sloan Kettering Cancer Center, New York, NY.

出版信息

J Clin Oncol. 2025 May 20;43(15):1751-1754. doi: 10.1200/JCO-25-00205. Epub 2025 Apr 11.

DOI:10.1200/JCO-25-00205
PMID:40215432
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12084127/
Abstract

In the article that accompanies this editorial, Gallois et al. investigate the added value of transcriptomic signatures incorporating tumoral, stromal and immune features to refine the prognosis assessment of stage III colon cancer after resection. If prospectively validated, these findings pave the way for a personalized adjuvant strategy and possibly omission of adjuvant treatment for patients with very low risk disease or therapeutic intensification for high risk disease.

摘要

在随本社论刊发的文章中，加洛瓦等人研究了整合肿瘤、基质和免疫特征的转录组特征在完善III期结肠癌切除术后预后评估方面的附加价值。如果这些发现得到前瞻性验证，将为个性化辅助治疗策略铺平道路，对于极低风险疾病的患者可能无需进行辅助治疗，而对于高风险疾病的患者则可能加强治疗。