Lee Hamin, Nam Jin-Wu, Kim Mi Kyung, Kim Inah, Kim Yu-Mi, Park Boyoung
Department of Preventive Medicine, Hanyang University College of Medicine, Seoul, South Korea.
Department of Life Science, Hanyang University College of Natural Sciences, Seoul, South Korea; Hanyang Institute of Bioscience and Biotechnology, Hanyang University, Seoul, South Korea.
Cancer Epidemiol. 2025 Aug;97:102817. doi: 10.1016/j.canep.2025.102817. Epub 2025 Apr 12.
Owing to the short history of the National Cancer Registry, self-reported cancer history is an important source of morbidity in recently constructed cohorts or cohorts of the older population. This study aimed to evaluate the validity of the self-reported cancer history gathered through the Korean Atomic Bomb Survivor Cohort (K-ABC) study compared with the Korean Central Cancer Registry (KCCR).
Among the K-ABC participants recruited from 2020 to 2024, self-reported cancer history from 1756 participants was linked to the KCCR. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and kappa coefficient were estimated for each cancer site.
Among 181 participants with a minimum of one record in the KCCR, 164 reported a history of cancer. Overall cancers and each cancer site showed high sensitivity, PPV, and kappa values of > 80 %, > 66 %, and > 0.73, respectively, except for cervical and lung cancers, which showed sensitivities of < 50 % and kappa values of 0.33 and 0.59, respectively. High specificity and NPV (≥99 %) were observed for all cancer sites.
The validity of the self-reported cancer history of the K-ABC showed a relatively high level of agreement with the KCCR records. These findings indicate that self-reported cancer information from the K-ABC study is valid for all sexes and ages but needs consideration when used for evaluating cervical and lung cancer.
由于国家癌症登记处的历史较短，自我报告的癌症病史是近期构建的队列或老年人群队列中发病率的重要来源。本研究旨在评估通过韩国原子弹幸存者队列（K-ABC）研究收集的自我报告癌症病史与韩国中央癌症登记处（KCCR）相比的有效性。
在2020年至2024年招募的K-ABC参与者中，1756名参与者自我报告的癌症病史与KCCR相关联。对每个癌症部位估计敏感性、特异性、阳性预测值（PPV）、阴性预测值（NPV）和kappa系数。
在KCCR中至少有一条记录的181名参与者中，164名报告有癌症病史。除宫颈癌和肺癌外，总体癌症和每个癌症部位的敏感性、PPV和kappa值分别显示出>80%、>66%和>0.73的高水平，宫颈癌和肺癌的敏感性分别<50%，kappa值分别为0.33和0.59。所有癌症部位均观察到高特异性和NPV（≥99%）。
K-ABC自我报告癌症病史的有效性与KCCR记录显示出相对较高的一致性水平。这些发现表明，K-ABC研究中自我报告的癌症信息对所有性别和年龄都是有效的，但在用于评估宫颈癌和肺癌时需要考虑。
