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The Impact of Glucagon-Like Peptide-1 Receptor Agonists on Pharmacokinetics and Toxicokinetics: Is a New Diagnostic and Therapeutic Framework Needed?

作者信息

Whitledge James D, Kennedy Joseph, Watson C James, Malley Carin, Simone Karen, Neavyn Mark

机构信息

Northern New England Poison Center, Portland, ME, USA.

Department of Emergency Medicine, University of Vermont Health Network, Burlington, VT, USA.

出版信息

J Med Toxicol. 2025 Jul;21(3):301-303. doi: 10.1007/s13181-025-01075-8. Epub 2025 Apr 11.

DOI:10.1007/s13181-025-01075-8
PMID:40216700
Abstract
摘要

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本文引用的文献

1
GLP-1RA-induced delays in gastrointestinal motility: Predicted effects on coadministered drug absorption by PBPK analysis.胰高血糖素样肽-1受体激动剂引起的胃肠动力延迟：通过生理药代动力学（PBPK）分析预测对联合给药药物吸收的影响。
Pharmacotherapy. 2025 Apr;45(4):211-219. doi: 10.1002/phar.70007. Epub 2025 Feb 23.
2
Physiology and Pharmacology of Effects of GLP-1-based Therapies on Gastric, Biliary and Intestinal Motility.基于胰高血糖素样肽-1的疗法对胃、胆道和肠道运动影响的生理学与药理学
Endocrinology. 2024 Nov 26;166(1). doi: 10.1210/endocr/bqae155.
3
Multisociety clinical practice guidance for the safe use of glucagon-like peptide-1 receptor agonists in the perioperative period.
围手术期安全使用胰高血糖素样肽-1受体激动剂的多学会临床实践指南。
Surg Obes Relat Dis. 2024 Dec;20(12):1183-1186. doi: 10.1016/j.soard.2024.08.033. Epub 2024 Oct 29.
4
Potential role of glucagon-like peptide-1 (GLP-1) receptor agonists in substance use disorder: A systematic review of randomized trials.胰高血糖素样肽-1（GLP-1）受体激动剂在物质使用障碍中的潜在作用：一项随机试验的系统评价。
Drug Alcohol Depend. 2024 Nov 1;264:112424. doi: 10.1016/j.drugalcdep.2024.112424. Epub 2024 Sep 7.
5
Glucagon-Like Peptide-1 Receptor Agonist Cases Reported to United States Poison Centers, 2017-2022.2017-2022 年向美国中毒控制中心报告的胰高血糖素样肽-1 受体激动剂病例。
J Med Toxicol. 2024 Apr;20(2):193-204. doi: 10.1007/s13181-024-00999-x. Epub 2024 Feb 29.
6
Drug-Drug Interactions Between Glucagon-Like Peptide 1 Receptor Agonists and Oral Medications: A Systematic Review.胰高血糖素样肽 1 受体激动剂与口服药物的药物相互作用：系统评价。
Drug Saf. 2024 May;47(5):439-451. doi: 10.1007/s40264-023-01392-3. Epub 2024 Jan 25.
7
Amanita Mushroom Toxin Poisoning in Los Angeles County.洛杉矶县的鹅膏菌毒素中毒事件
ACG Case Rep J. 2023 Dec 28;11(1):e01246. doi: 10.14309/crj.0000000000001246. eCollection 2024 Jan.
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JAMA. 2023 Dec 19;330(23):2267-2274. doi: 10.1001/jama.2023.24391.
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Am J Gastroenterol. 2024 Jun 1;119(6):1154-1157. doi: 10.14309/ajg.0000000000002564. Epub 2023 Oct 19.
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Risk of Gastrointestinal Adverse Events Associated With Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss.胰高血糖素样肽-1受体激动剂用于减肥时胃肠道不良事件的风险
JAMA. 2023 Nov 14;330(18):1795-1797. doi: 10.1001/jama.2023.19574.