Ren Mingfei, Yao Jingjing, Yang Dicheng, Zhu Jingyao, Dai Kun, Zhong Yujun, Zhu Jun, Tang Liang, Xu Yan, Yu Jiangming
School of Materials Science and Engineering, Shanghai Jiao Tong University, No.800 Dongchuan Road, Shanghai, 200240, China.
National Engineering Research Center for Nanotechnology, No.28, East Jiang Chuan Road, Shanghai, 200241, China.
Sci Rep. 2025 Apr 11;15(1):12449. doi: 10.1038/s41598-024-84416-x.
Globally, burns pose a significant health concern, impairing the skin's normal function and elevating the risk of bacterial infection. Traditional burn dressings often fail to deliver the anticipated therapeutic benefits. Hence, there is an urgent need to develop an ideal wound dressing that exhibits satisfactory antibacterial properties, biocompatibility, and the ability to expedite burn wound healing. Here, we prepared chitosan-based hydrogel (CS/GP), and then loaded copper-tin -sulfur (CuSnS) synthesized by hydrothermal method into the hydrogel to construct a new hydrogel dressing (CS/GP/CuSnS). In vitro antibacterial tests demonstrated that the CS/GP/CuSnS hydrogel dressing exhibits considerable antibacterial properties, achieving an antibacterial rate exceeding 95% after 4 h of contact with Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). Additionally, CCK-8 and live/dead cell staining experiments confirmed the dressing's good biocompatibility. Furthermore, in vivo experiments confirmed that the CS/GP/CuSnS hydrogel dressing demonstrates superior wound healing performance compared to the control group. In conclusion, the CS/GP/CuSnS hydrogel shows potential application prospects as a burn wound dressing.
在全球范围内，烧伤是一个重大的健康问题，它会损害皮肤的正常功能并增加细菌感染的风险。传统的烧伤敷料往往无法带来预期的治疗效果。因此，迫切需要开发一种理想的伤口敷料，该敷料应具有令人满意的抗菌性能、生物相容性以及促进烧伤伤口愈合的能力。在此，我们制备了基于壳聚糖的水凝胶（CS/GP），然后将通过水热法合成的铜锡硫（CuSnS）负载到水凝胶中，构建了一种新型水凝胶敷料（CS/GP/CuSnS）。体外抗菌测试表明，CS/GP/CuSnS水凝胶敷料具有相当可观的抗菌性能，与金黄色葡萄球菌（S. aureus）和大肠杆菌（E. coli）接触4小时后，抗菌率超过95%。此外，CCK-8和活/死细胞染色实验证实了该敷料具有良好的生物相容性。此外，体内实验证实，与对照组相比，CS/GP/CuSnS水凝胶敷料具有优异的伤口愈合性能。总之，CS/GP/CuSnS水凝胶作为烧伤伤口敷料具有潜在的应用前景。
