Tong Xin, Luo Rong, Hu Xiao, Zhou Dong, An Dongmei
Department of Neurology, West China Hospital, Sichuan University, No. 37 Guoxue Road, Chengdu, 610041, Sichuan, China.
Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, 610041, China.
Acta Epileptol. 2025 Jan 6;7(1):4. doi: 10.1186/s42494-024-00180-5.
To investigate the prevalence, risk factors, and impacts of childhood trauma in Chinese patients with psychogenic non-epileptic seizures (PNES) compared to the healthy population.
Patients with PNES and sex- and age-matched healthy controls were recruited. All the participants were interviewed to collect demographics, information of childhood environment, and clinical characteristics. Each participant completed the Childhood Trauma Questionnaire-Short Form (CTQ-SF), the Dissociative Experiences Scale (DES), and the Symptom Checklist-90 (SCL-90). Factors associated with childhood trauma, psychiatric symptoms, and clinical features of PNES were analyzed.
A total of 35 PNES patients and 34 controls were included in this study. Compared with the controls, the PNES patients reported a higher rate of childhood trauma and more severe psychiatric symptoms. In the PNES patients, early separation from parents was related to more types of childhood trauma and emotional neglect (EN); older age and rural residence during childhood were related to sexual abuse (SA). Moreover, childhood SA and trauma accumulation were correlated with the present psychiatric symptoms. Childhood trauma and rural residence were associated with dissociative symptoms. Separation from parents predicted an earlier PNES onset, whereas childhood SA predicted a later onset. More severe dissociative symptoms were associated with higher seizure frequency.
Childhood trauma is related to the development of PNES and the compromised mental health in PNES patients. This highlights the importance of child protection for preventing psychiatric disorders such as PNES.
与健康人群相比，调查中国心因性非癫痫性发作（PNES）患者童年创伤的患病率、危险因素及影响。
招募PNES患者及性别和年龄匹配的健康对照。对所有参与者进行访谈以收集人口统计学信息、童年环境信息和临床特征。每位参与者完成儿童创伤问卷简表（CTQ-SF）、解离体验量表（DES）和症状自评量表90（SCL-90）。分析与童年创伤、精神症状及PNES临床特征相关的因素。
本研究共纳入35例PNES患者和34例对照。与对照组相比，PNES患者童年创伤发生率更高，精神症状更严重。在PNES患者中，早期与父母分离与更多类型的童年创伤及情感忽视（EN）相关；年龄较大及童年时居住在农村与性虐待（SA）相关。此外，童年SA和创伤累积与当前精神症状相关。童年创伤和农村居住与解离症状相关。与父母分离预示着PNES发病较早，而童年SA预示着发病较晚。更严重的解离症状与更高的发作频率相关。
童年创伤与PNES的发生及PNES患者心理健康受损有关。这凸显了儿童保护对预防诸如PNES等精神障碍的重要性。
