Osiak-Wicha Cezary, Kras Katarzyna, Tomaszewska Ewa, Muszyński Siemowit, Grochecki Paweł, Kotlińska Jolanta H, Słowik Tymoteusz, Świetlicki Michał, Arciszewski Kamil, Lubec Gert, Arciszewski Marcin B
Department of Animal Anatomy and Histology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Akademicka 12, 20-950 Lublin, Poland.
Department of Animal Physiology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Akademicka 12, 20-950 Lublin, Poland.
J Clin Med. 2025 Apr 2;14(7):2427. doi: 10.3390/jcm14072427.
Post-traumatic stress disorder (PTSD) has been associated with negative effects on bone health, potentially leading to reduced bone mass, altered geometry, and impaired mechanical strength. However, the extent of these changes and possible pharmacological interventions remains unclear. This study aimed to assess the impact of PTSD on bone properties and evaluate the therapeutic potential of CE-123 in mitigating PTSD-induced skeletal deterioration. Additionally, we examined the effects of CE-123 on healthy bone to determine its broader influence on skeletal integrity and growth. We conducted an experiment using female Wistar rats divided into four groups: Control, PTSD, Control+CE-123, and PTSD+CE-123. PTSD was induced using a validated stress paradigm, and CE-123 was administered to evaluate its effects on bone properties. Morphometric, densitometric, and mechanical parameters of the tibia and femur were analyzed, along with growth plate measurements to assess potential effects on skeletal development. PTSD led to significant reductions in bone mineral density, bone mass, and mechanical properties, particularly in cortical thickness and relative bone weight, suggesting increased bone fragility. CE-123 treatment in PTSD-exposed rats prevented some of these adverse effects but did not fully restore bone integrity. In healthy rats, CE-123 increased bone length and growth plate size, particularly in the proliferative and resting zones, indicating a stimulatory effect on bone growth. PTSD negatively affects bone structure and mechanical strength, while CE-123 shows a potential to mitigate these effects. However, its influence on healthy bones raises questions about its long-term impact on skeletal development. Further studies are needed to evaluate CE-123's clinical applicability and safety, particularly in younger populations.
创伤后应激障碍（PTSD）已被证实会对骨骼健康产生负面影响，可能导致骨量减少、骨骼几何形状改变以及机械强度受损。然而，这些变化的程度以及可能的药物干预措施仍不明确。本研究旨在评估PTSD对骨骼特性的影响，并评估CE - 123在减轻PTSD引起的骨骼退化方面的治疗潜力。此外，我们还研究了CE - 123对健康骨骼的影响，以确定其对骨骼完整性和生长的更广泛影响。我们使用雌性Wistar大鼠进行了一项实验，将其分为四组：对照组、PTSD组、对照组 + CE - 123组和PTSD + CE - 123组。采用经过验证的应激范式诱导PTSD，并给予CE - 123以评估其对骨骼特性的影响。分析了胫骨和股骨的形态计量学、密度测定和力学参数，以及生长板测量结果，以评估对骨骼发育的潜在影响。PTSD导致骨矿物质密度、骨量和力学性能显著降低，尤其是皮质厚度和相对骨重量，表明骨脆性增加。在暴露于PTSD的大鼠中，CE - 123治疗可预防部分这些不良反应，但未能完全恢复骨骼完整性。在健康大鼠中，CE - 123增加了骨长度和生长板大小，特别是在增殖区和静止区，表明对骨骼生长有刺激作用。PTSD对骨骼结构和机械强度有负面影响，而CE - 123显示出减轻这些影响的潜力。然而，其对健康骨骼的影响引发了关于其对骨骼发育长期影响的疑问。需要进一步研究来评估CE - 123的临床适用性和安全性，特别是在年轻人群中。
