Gao Jun, Sun Lingwei, Liao Rongrong, Lyu Yuhua, Zhang Shushan, Xu Jiehuan, He Mengqian, Wu Caifeng, Zhang Defu, Lin Yuexia, Dai Jianjun
Institute of Animal Science and Veterinary Medicine, Shanghai Academy of Agricultural Sciences, Shanghai 201106, China.
Shanghai Municipal Key Laboratory of Agri-Genetics and Breeding, Shanghai 201106, China.
Animals (Basel). 2025 Mar 28;15(7):979. doi: 10.3390/ani15070979.
The conservation and utilization of livestock genetic resources is essential for the maintenance of biodiversity and breed innovation. Whole genome sequencing (WGS) was performed on 90 samples from Chinese Yangtze River Delta White goats (YRD), sourced from two populations of Chongming island white goats and Haimen white goats, aiming to dissect their genomic characteristics. In addition, 262 WGS data from nine other breeds of goats were downloaded from the NCBI database. These WGS data obtained were used to identify and analyze genetic variation with the goat reference genome, and the genetic structure of goat populations was analyzed. Through selective sweep analysis, the selection-signature genes and their polymorphic features were identified. It was found that the most significant genomic selection region in YRD goats was in the region of 62.9-64.6 Mb on chromosome 13, which contained genes related to the coat color and muscle growth of the goats. Nucleotide diversity of MYH7B, a gene related to the development of the goat's skeletal muscle, within the Yangtze River Delta white goat population was significantly lower than in other domestic and foreign goat breeds, suggesting that the gene was subject to selection. In addition, the IGF2BP2 gene, reported to be associated with litter size in goats, showed clear selection-signature characteristics in the Boer goats compared to the YRD goats.
家畜遗传资源的保护与利用对于维护生物多样性和品种创新至关重要。对来自中国长江三角洲白山羊（YRD）的90个样本进行了全基因组测序（WGS），这些样本源自崇明岛白山羊和海门白山羊两个群体，旨在剖析它们的基因组特征。此外，从NCBI数据库下载了来自其他九个山羊品种的262个WGS数据。利用获得的这些WGS数据与山羊参考基因组进行遗传变异的鉴定和分析，并分析山羊群体的遗传结构。通过选择性清除分析，鉴定出选择特征基因及其多态性特征。研究发现，长江三角洲白山羊中最显著的基因组选择区域位于13号染色体上62.9 - 64.6 Mb的区域，该区域包含与山羊毛色和肌肉生长相关的基因。长江三角洲白山羊群体中与山羊骨骼肌发育相关的基因MYH7B的核苷酸多样性显著低于其他国内外山羊品种，表明该基因受到了选择。此外，据报道与山羊产仔数相关的IGF2BP2基因，与长江三角洲白山羊相比，在波尔山羊中表现出明显的选择特征。
