Golder Janet, Bauer Judith, Barker Lisa A, Lemoh Christopher, Gibson Simone, Davidson Zoe E
Department of Nutrition, Dietetics and Food, School of Clinical Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Level 1, 264 Ferntree Gully Road, Notting Hill 3168, VIC, Australia.
Allied Health, Monash Health, 400 Warrigal Rd., Cheltenham 3192, VIC, Australia.
Nutrients. 2025 Mar 25;17(7):1131. doi: 10.3390/nu17071131.
: Assessment of vitamin C status rarely occurs in hospital patients within high-income countries on the assumption that vitamin C deficiency (VCD) is rare, and evidence on prevalence, risk factors, and clinical outcomes of VCD is limited. This study aimed to describe the prevalence of VCD, characteristics of patients with VCD, and identify risk factors and clinical outcomes associated with VCD status in adult hospitalised patients. : This retrospective observational study included adult inpatients from five metropolitan hospitals within a single public health service in Australia which provides tertiary, acute, and sub-acute care, over a 3.5-year period. Non-fasting vitamin C levels were examined for the prevalence of VCD, defined as <11.4 µmol/L. Multivariate regression models were used to identify risk factors and clinical outcomes associated with VCD. : The prevalence of VCD was 22.9% (n = 1791), comprising 23.2% (n = 1717) and 16.2% (n = 74) within acute and sub-acute settings, respectively. VCD prevalence was high in acute setting subgroups including patients with malnutrition (30%, n = 611) and patients admitted to ICU during hospitalisation (37.3%, n = 327). Malnutrition (OR 1.50, 95% CI 1.19-1.91, < 0.001) and male gender (OR 1.47, 95% CI 1.17-1.86, = 0.001) were associated with VCD. VCD was not associated with clinical outcomes including in-hospital death, hospital or intensive care unit LOS, or hospital-acquired complications. : VCD exists within adult hospital patients in high-income countries, and early, targeted detection of VCD in this setting is warranted. Further research is needed to explore the impact of VCD on hospital clinical outcomes.
在高收入国家，由于假定维生素C缺乏症（VCD）很少见，医院患者中很少对维生素C状况进行评估，而且关于VCD的患病率、危险因素和临床结局的证据有限。本研究旨在描述成人住院患者中VCD的患病率、VCD患者的特征，并确定与VCD状况相关的危险因素和临床结局。 ：这项回顾性观察性研究纳入了澳大利亚单一公共卫生服务机构内五家大都市医院的成年住院患者，该机构提供三级、急性和亚急性护理，为期3.5年。检测非空腹维生素C水平以确定VCD的患病率，VCD定义为<11.4 µmol/L。使用多变量回归模型确定与VCD相关的危险因素和临床结局。 ：VCD的患病率为22.9%（n = 1791），急性和亚急性环境中的患病率分别为23.2%（n = 1717）和16.2%（n = 74）。在急性环境亚组中，VCD患病率较高，包括营养不良患者（30%，n = 611）和住院期间入住重症监护病房的患者（37.3%，n = 327）。营养不良（OR 1.50，95%CI 1.19 - 1.91，<0.001）和男性（OR 1.47，95%CI 1.17 - 1.86，= 0.001）与VCD相关。VCD与包括住院死亡、住院或重症监护病房住院时间或医院获得性并发症在内的临床结局无关。 ：高收入国家的成年住院患者中存在VCD，在此环境中早期、有针对性地检测VCD是有必要的。需要进一步研究以探讨VCD对医院临床结局的影响。
