Menichetti Francesca, Berteotti Chiara, Schirinzi Vittoria, Poli Carolina, Arrighi Roberta, Leone Alessandro
International Center for the Assessment of Nutritional Status and the Development of Dietary Intervention Strategies (ICANS-DIS), Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, 20133 Milan, Italy.
PRISM Lab, Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum University of Bologna, 40126 Bologna, Italy.
Nutrients. 2025 Apr 3;17(7):1258. doi: 10.3390/nu17071258.
The prevalence of hypertension is increasing worldwide, in particular in developing countries. Anti-hypertensive drugs are commonly used to treat hypertension. However, in developing countries, where access to health care is scarce and the supply system is poor, anti-hypertensive drugs may not always be available. is a plant widely found in developing countries, with its leaves, seeds, flowers, roots, and pods used both for nutritional purposes and in traditional medicine to treat various diseases, including hypertension. This review summarizes the evidence, both in animal and human models, about the antihypertensive effects of different parts of , discusses possible mechanisms of action, explores its bioactive compounds with potential antihypertensive properties, and highlights the limitations of its use as a hypotensive agent. Many preclinical studies attribute antihypertensive properties to , particularly the leaves. However, it is premature to draw firm conclusions, as there is a great lack of randomized controlled trials demonstrating its real efficacy. The mechanisms of action and the compounds responsible for the hypotensive effect have not yet been fully elucidated. Therefore, further clinical trials showing its efficacy are strongly required before promoting Moringa for therapeutic purposes. At present, Moringa remains a plant with nutritional and pharmacological potential.
高血压的患病率在全球范围内不断上升，尤其是在发展中国家。抗高血压药物常用于治疗高血压。然而，在医疗保健资源稀缺且供应系统不佳的发展中国家，抗高血压药物可能并非总能获得。辣木是一种在发展中国家广泛分布的植物，其叶、种子、花、根和豆荚既用于营养目的，也用于传统医学治疗包括高血压在内的各种疾病。本综述总结了动物和人体模型中有关辣木不同部位降压作用的证据，讨论了可能的作用机制，探索了具有潜在降压特性的生物活性化合物，并强调了其作为降压药使用的局限性。许多临床前研究将降压特性归因于辣木，尤其是其叶子。然而，由于非常缺乏证明其实际疗效的随机对照试验，现在得出确凿结论还为时过早。其作用机制和导致降压作用的化合物尚未完全阐明。因此，在推广辣木用于治疗目的之前，强烈需要需要进一步进一步的临床试验以证明其疗效。目前，辣木仍然是一种具有营养和药理潜力的植物。
