Immunonutrition Research Group, Department of Metabolism and Nutrition, Institute of Food Science and Technology and Nutrition (ICTAN)-CSIC, 28040 Madrid, Spain.
Cea Bermúdez Primary Health Care Centre, Madrid Health Service, 28003 Madrid, Spain.
Nutrients. 2022 May 5;14(9):1937. doi: 10.3390/nu14091937.
Different parts of the Lam. (MO) tree are consumed as food or food supplements for their nutritional and medicinal value; however, very few human studies have been published on the topic. The current work was aimed to provide ancillary analysis to the antidiabetic effects previously reported in a double-blind, randomized, placebo-controlled, parallel group intervention conducted in patients with prediabetes. Thus, the effect of MO leaves on blood and fecal inflammatory markers, serum lipid profile, plasma antioxidant capacity and blood pressure was studied in participants who consumed 6 × 400 mg capsule/day of MO dry leaf powder (MO, = 31) or placebo (PLC, = 34) over 12 weeks. Differences between groups were assessed using each biomarker's change score with, adjustment for fat status and the baseline value. In addition, a decision tree analysis was performed to find individual characteristics influencing the glycemic response to MO supplementation. No differences in the biomarker's change scores were found between the groups; however, the decision tree analysis revealed that plasma TNF-α was a significant predictor of the subject's HbA1c response (improvement YES/NO; 77% correct classification) in the MO group. In conclusion, TNF-α seems to be a key factor to identify potential respondents to MO leaf powder.
[原文] Lam. (MO) 树的不同部位因其营养价值和药用价值而被作为食物或食物补充剂食用；然而，关于这一主题的人体研究很少。目前的工作旨在为以前在糖尿病前期患者中进行的双盲、随机、安慰剂对照、平行组干预中报告的抗糖尿病作用提供辅助分析。因此，在 12 周内，参与者每天食用 6×400mg MO 干叶粉（MO，n=31）或安慰剂（PLC，n=34），研究 MO 叶对血液和粪便炎症标志物、血清脂质谱、血浆抗氧化能力和血压的影响。使用每个生物标志物的变化分数评估组间差异，并调整脂肪状况和基线值。此外，还进行了决策树分析，以寻找影响 MO 补充对血糖反应的个体特征。组间生物标志物变化分数无差异；然而，决策树分析显示，MO 组中 TNF-α 是受试者 HbA1c 反应（改善 YES/NO；77%正确分类）的显著预测因子。总之，TNF-α似乎是识别 MO 叶粉潜在应答者的关键因素。
