Zuo Xiaoling, Sun Weijing, Wu Yutong, Gu Hanliu, Chen Tao, Zhang Ting, Liu Xiaoying, Zhang Jianwei, Wang Li
Department of Biomedical Engineering, School of Big Health and Intelligent Engineering, Chengdu Medical College, Chengdu 610500, China.
Polymers (Basel). 2025 Mar 25;17(7):872. doi: 10.3390/polym17070872.
Tissue-engineered biocompatible scaffolds could mimic the extracellular matrix structure for cell adhesion and proliferation; however, patients suffer from large volume implantation. In this study, a thermal sensitive shape memory polyurethane porous 3D scaffold based on poly(ε-caprolactone) and poly(ethylene glycol adipate) was developed, utilizing the water-splitting property of aliphatic hexamethylene diisocyanate (HDI) to crosslink rigid segments during the polymerization process. The chemical structure, microstructure, and morphology, as well as mechanical strength, of the scaffolds were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), a scanning electron microscope (SEM), and tensile tests. The results show that gas foaming action caused by the release of CO occurred simultaneously in the reactive process, resulting in the interconnective porous structure of the PU scaffolds with a porosity of over 70% and pore sizes from 100 μm to 800 μm. Additionally, after programming to a temporary shape, the scaffolds could recover to their initial shapes and could be programmed into various shapes according to different defects. These smart shape-changeable scaffolds with high porosity and good physio-chemical properties are a promising material for minimally invasive tissue engineering.
组织工程生物相容性支架可以模拟细胞外基质结构以促进细胞黏附和增殖；然而，患者会面临大体积植入的问题。在本研究中，基于聚（ε-己内酯）和聚（己二酸乙二醇酯）开发了一种热敏形状记忆聚氨酯多孔3D支架，利用脂肪族六亚甲基二异氰酸酯（HDI）在聚合过程中的水解特性交联刚性链段。通过傅里叶变换红外光谱（FTIR）、X射线衍射（XRD）、扫描电子显微镜（SEM）和拉伸试验对支架的化学结构、微观结构、形态以及机械强度进行了表征。结果表明，在反应过程中，由CO释放引起的气体发泡作用同时发生，导致PU支架具有相互连通的多孔结构，孔隙率超过70%，孔径为100μm至800μm。此外，在编程为临时形状后，支架可以恢复到其初始形状，并可根据不同的缺损编程为各种形状。这些具有高孔隙率和良好理化性质的智能形状可变支架是微创组织工程中有前景的材料。
