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环境因素对新生儿诱导染色体畸变的影响。

Effect of environmental factors on induced chromosomal aberrations in newborns.

作者信息

Kucerová M, Polívková Z, Gregor V

出版信息

Mutat Res. 1985 Aug;143(4):271-4. doi: 10.1016/0165-7992(85)90092-2.

Abstract

Repeated blood collection was performed in newborns living in 3 distinct areas of the country with different levels of chemical pollution in the environment. Both the classical and SCE techniques were used in parallel. Blood samples from mothers and 1-year-old infants in the same area were also analysed to compare age-dependent sensitivity to mutagens. Cells with classical aberrations increased significantly according to higher chemical pollution, the levels of SCEs were not significantly changed. No age-dependent difference in sensitivity to chemical mutagens was found.

摘要

对生活在该国三个不同地区、环境化学污染程度不同的新生儿进行了反复采血。同时使用了经典技术和姐妹染色单体互换(SCE)技术。还对同一地区母亲和1岁婴儿的血样进行了分析,以比较不同年龄对诱变剂的敏感性。随着化学污染程度的增加,出现经典畸变的细胞显著增多,而SCE水平没有显著变化。未发现对化学诱变剂的敏感性存在年龄依赖性差异。

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