Youssef Mohamed A, Gosnell Joseph, Stevenson Heather L
Division of Nephrology, The University of Texas Medical Branch, Galveston, TX, USA.
Department of Pathology, The University of Texas Medical Branch, Galveston, TX, USA.
Int J Surg Pathol. 2025 Oct;33(7):1658-1665. doi: 10.1177/10668969251331176. Epub 2025 Apr 13.
Biliary adenofibroma (BAF) is a rare hepatic tumor with a high risk for malignant transformation. Since BAF shares many characteristics with other hepatic lesions, diagnosis usually requires meticulous evaluation. The literature review revealed 29 reported patients of BAF, with malignant transformation occurring in 45% of patients. High Ki-67 (>40%) and mutated/overexpressed p53 staining were associated with malignancy, but some patients also had malignant features with low Ki-67 (≤10%) and wild-type p53. We report an elderly female patient who was initially diagnosed with benign liver hemangioma based on an abdominal ultrasound. The mass enlarged by 4 cm raising concerns about potential complications, including hemorrhage, which led to hepatic segmental resection. Histopathological examination revealed predominantly BAF features with focal areas that showed malignant cholangiocarcinoma characteristics.
胆管腺纤维瘤（BAF）是一种罕见的肝脏肿瘤，具有较高的恶变风险。由于BAF与其他肝脏病变有许多共同特征，诊断通常需要细致评估。文献回顾显示有29例BAF患者的报道，其中45%的患者发生了恶变。高Ki-67（>40%）以及p53染色突变/过表达与恶性肿瘤相关，但一些患者Ki-67低（≤10%）且p53为野生型时也具有恶性特征。我们报告一名老年女性患者，最初根据腹部超声诊断为良性肝血管瘤。肿块增大了4厘米，引发了对包括出血在内的潜在并发症的担忧，这导致了肝段切除术。组织病理学检查显示主要为BAF特征，局部区域表现出恶性胆管癌特征。
