Wu Zemin, Li Bing, Zhu Wenke, Shang JingJing, Yao Jiapei, Huang Yong, Yin Jiansong, Zhou Xindie
Department of Emergency, Wujin Hospital of Traditional Chinese Medicine, Changzhou, Jiangsu, China.
Department of Orthopedics, Wujin Hospital of Traditional Chinese Medicine, Changzhou, Jiangsu, China.
Biomark Med. 2025 May;19(9):341-348. doi: 10.1080/17520363.2025.2491302. Epub 2025 Apr 13.
Abnormalities of lymphocyte subsets have been observed in patients with pneumonia. This study investigated the diagnostic efficiency of lymphocyte subsets in the detection of early-stage postoperative pneumonia (POP) among older patients undergoing hip fracture surgery.
A total of 576 patients with hip fracture were recruited and analyzed for lymphocyte subsets on the first postoperative day.
The incidence of POP was 10.6% (61/576) from March 2016 to December 2023. The area under the curve for the percentage of CD8+ HLA-DR+ T cells was higher than that of CD4+ T and CD4+ CD45RA+ T cells. A high percentage of CD8+ HLA-DR+ T cells was significantly associated with an increased occurrence of POP. The positive findings remained significant after adjusting for confounding factors. Among the multiple complications, patients with diabetes tended to have higher percentages of CD8+ HLA-DR+ T cells.
The percentage of CD8+ HLA-DR+ T cells had a good predictive value for detecting early-stage POP. Multi-center prospective studies with larger sample sizes are needed to verify this finding.
肺炎患者中已观察到淋巴细胞亚群异常。本研究调查了淋巴细胞亚群在髋部骨折手术老年患者术后早期肺炎（POP）检测中的诊断效率。
共招募576例髋部骨折患者，并在术后第一天分析其淋巴细胞亚群。
2016年3月至2023年12月期间，POP的发生率为10.6%（61/576）。CD8 + HLA - DR + T细胞百分比的曲线下面积高于CD4 + T细胞和CD4 + CD45RA + T细胞。CD8 + HLA - DR + T细胞的高百分比与POP发生率增加显著相关。在调整混杂因素后，阳性结果仍然显著。在多种并发症中，糖尿病患者的CD8 + HLA - DR + T细胞百分比往往更高。
CD8 + HLA - DR + T细胞百分比对早期POP检测具有良好的预测价值。需要开展更大样本量的多中心前瞻性研究来验证这一发现。
