, , and Polymorphisms May Play a Role in -mediated Development of Alzheimer's-type Dementia.

OBJECTIVE

The brain-derived neurotrophic factor (BDNF) playing a crucial role in neuron survival and function, particularly in neurodegenerative diseases like Alzheimer's disease (AD). Our study seeks to explore polymorphisms in miRNAs that regulate the gene in individuals with AD, and to reveal the relationship between these polymorphisms and genotypes.

METHODS

Seventy AD patients who applied to the Psychiatry outpatient clinic were recruited for the study as well as 70 healthy individuals in the same age. The cases were examined for 5 miRNAs regulating and 2 SNPs using the SNPType method on the Fluidigm platform.

RESULTS

In comparisons of the genotype distributions for three polymorphisms (, , ) ( < 0.01 all) and the allele frequencies for two polymorphisms (, ) ( < 0.01) detected significant differences between groups. While the genotype was detected in 4.50% of the AD group, no individual with this genotype was observed in the control group. When the correlation between miRNA polymorphisms and genotypic distributions were investigated, the polymorphism showed a statistically significant positive correlation with the genotype and a statistically significant negative correlation with the genotype ( < 0.08 and < 0.001, respectively). On the other hand, the polymorphism exhibited a statistically significant positive correlation with the and genotypes ( < 0.03 and < 0.07, respectively).

CONCLUSION

These findings could potentially offer insights into the mechanisms underlying AD.