Ye Xiaohua, Lou Chunmin, Shen Zhe
Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China.
Department of Gastroenterology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, China.
Mol Nutr Food Res. 2025 Jun;69(11):e70059. doi: 10.1002/mnfr.70059. Epub 2025 Apr 13.
The EAT-Lancet Commission recommends a sustainable, health-focused diet, but its impact on inflammatory bowel disease (IBD) and metabolic mechanisms remains unclear. This study explores the association between the EAT-Lancet diet and IBD risk. We included 187 558 participants from the UK Biobank, free from IBD at baseline. Dietary intake was assessed using a validated 24-h dietary recall, and an EAT-Lancet diet score was calculated. Incident IBD cases were identified through primary care, hospital data, and death registries. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Over a mean follow-up of 13.15 years, 571 cases of Crohn's disease (CD) and 1066 of ulcerative colitis (UC) were recorded. HRs per 1-point increase in the EAT-Lancet score were 0.95 (95% CI: 0.91-0.98) for IBD, 0.95 (95% CI: 0.91-1.00) for UC, and 0.93 (95% CI: 0.87-0.98) for CD. Seven metabolites were identified as mediators, accounting for 10.7% of the association. Greater adherence to the EAT-Lancet diet was associated with a trend toward reduced IBD risk, with identified metabolites mediating this association. These findings emphasize the nutritional relevance of the EAT-Lancet diet in reducing IBD risk.
《柳叶刀-饮食委员会》建议采用以健康为重点的可持续饮食，但该饮食对炎症性肠病（IBD）及代谢机制的影响仍不明确。本研究探讨了《柳叶刀-饮食委员会》饮食与IBD风险之间的关联。我们纳入了英国生物银行的187558名参与者，这些参与者在基线时无IBD。使用经过验证的24小时饮食回顾法评估饮食摄入量，并计算《柳叶刀-饮食委员会》饮食评分。通过初级保健、医院数据和死亡登记处确定新发IBD病例。采用Cox比例风险模型估计风险比（HR）和95%置信区间（CI）。在平均13.15年的随访中，记录了571例克罗恩病（CD）和1066例溃疡性结肠炎（UC）病例。《柳叶刀-饮食委员会》评分每增加1分，IBD的HR为0.95（95%CI：0.91-0.98），UC为0.95（95%CI：0.91-1.00），CD为0.93（95%CI：0.87-0.98）。七种代谢物被确定为中介因素，占该关联的10.7%。对《柳叶刀-饮食委员会》饮食的更高依从性与IBD风险降低的趋势相关，已确定的代谢物介导了这种关联。这些发现强调了《柳叶刀-饮食委员会》饮食在降低IBD风险方面的营养相关性。
