腰椎间盘显微切除术后复发性疝和翻修手术相关的患者因素
Patient Factors Associated with Recurrent Herniation and Revision Surgery following Lumbar Microdiscectomy.
作者信息
Hoang Ryan, Song Junho, Tiao Justin, Ngan Alex, Hoang Timothy, J Corvi John, K Namiri Nikan, Chaudhary Saad, K Cho Samuel, C Hecht Andrew, Essig David, Virk Sohrab, D Katz Austen
机构信息
Department of Orthopaedic Surgery, The University of California Irvine School of Medicine , Irvine, USA.
Department of Orthopaedic Surgery, Icahn School of Medicine at Mount Sinai, New York, USA.
出版信息
Spine Surg Relat Res. 2024 Oct 5;9(2):244-250. doi: 10.22603/ssrr.2024-0148. eCollection 2025 Mar 27.
INTRODUCTION
Lumbar microdiscectomy is a commonly conducted surgical procedure for treating symptomatic lumbar disc herniations. Recurrence of herniation is a common cause of poor outcomes and the need for revision surgery, which occurs in as many as 21% of patients following primary discectomy. Identifying factors that are associated with the recurrence of herniation may be valuable for risk stratification and patient counseling. This study aimed to explore the relationship between various patient demographic variables and comorbidities and rates of reoperation after primary lumbar microdiscectomy.
METHODS
The American College of Surgeons National Surgical Quality Improvement Program database was queried for patients who were undergoing single-level primary lumbar microdiscectomy between 2016 and 2022. Eligibility for inclusion was determined by age >18 years and current procedural terminology codes 63030 and 63042. Patients with preoperative sepsis or cancer were excluded. Patient demographics, including age, race, ethnicity, and body mass index (BMI), and various comorbidities were compared between cohorts. To determine factors independently associated with the need for revision microdiscectomy, multivariable Poisson regressions were utilized.
RESULTS
In this study, a total of 65,121 primary discectomy patients were included, with a separate cohort of 6,971 patients undergoing revision discectomy. In comparison with primary patients, the revision cohort was older and had higher proportions of female and non-Hispanic White patients (all 0.001). The odds ratio for revision discectomy was greater in patients aged ≥65 years (1.577, 95% CI [1.480, 1.680]) than in those aged <45 years (>0.001). The odds ratio for revision was lower in Black (0.821, 95% CI [0.738, 0.914]) and Hispanic patients (0.819, 95% CI [0.738, 0.909]) when compared with non-Hispanic White patients (<0.001). Obese patients with BMI ≥35 (1.193, 95% CI [1.103, 1.290]) were at greater risk of revision than those with BMI <25 (<0.001). Diabetes (1.326, 95% CI [1.242, 1.416], <0.001), functional dependence (1.411, 95% CI [1.183, 1.683], <0.001), chronic obstructive pulmonary disorder (1.315, 95% CI [1.137, 1.512], <0.001), hypertension (1.398, 95% CI [1.330, 1.470], <0.001), and smoking (1.082, 95% CI [1.018, 1.151], =0.012) were associated with greater risk of revision. Poisson log-linear regression demonstrated sex ( =19.9, <0.001), race ( =39.5, <0.001), diabetes ( =10.1, =0.001), smoking ( =18.5, <0.001), hypertension ( =16.4, <0.001), age ( =102.4, <0.001), and BMI ( =4.7, =0.029) as significant predictors of revision, with steroid use ( =3.5, =0.061) and functional status ( =3.7, =0.055) approaching significance.
CONCLUSIONS
Patient demographics, comorbidities, and rehabilitative status may be significantly associated with rates of reherniation and revision surgery following lumbar microdiscectomy. We found that the significant predictors of revision surgery are functional dependence, advanced age, male sex, White race, obesity, diabetes, smoking, and hypertension. Early identification and attendance to the modifiable risk factors will aid patient guidance and outcomes following primary lumbar microdiscectomy.
引言
腰椎显微椎间盘切除术是治疗有症状的腰椎间盘突出症常用的外科手术。椎间盘突出复发是导致手术效果不佳和需要翻修手术的常见原因,在初次椎间盘切除术后多达21%的患者中会出现这种情况。识别与椎间盘突出复发相关的因素对于风险分层和患者咨询可能具有重要价值。本研究旨在探讨各种患者人口统计学变量和合并症与初次腰椎显微椎间盘切除术后再次手术率之间的关系。
方法
查询美国外科医师学会国家外科质量改进计划数据库中2016年至2022年间接受单节段初次腰椎显微椎间盘切除术的患者。纳入标准为年龄>18岁且当前手术操作术语编码为63030和63042。排除术前患有败血症或癌症的患者。比较各队列患者的人口统计学特征,包括年龄、种族、民族和体重指数(BMI)以及各种合并症。为确定与翻修显微椎间盘切除术需求独立相关的因素,采用多变量泊松回归分析。
结果
本研究共纳入65121例初次椎间盘切除术患者,另有6971例患者接受翻修椎间盘切除术。与初次手术患者相比,翻修队列患者年龄更大,女性和非西班牙裔白人患者比例更高(均P<0.001)。≥65岁患者翻修椎间盘切除术的比值比(1.577,95%可信区间[1.480, 1.680])高于<45岁患者(P<0.001)。与非西班牙裔白人患者相比,黑人(0.821,95%可信区间[0.738, 0.914])和西班牙裔患者(0.819,95%可信区间[0.738, 0.909])翻修的比值比更低(P<0.001)。BMI≥35的肥胖患者(1.193,95%可信区间[1.103, 1.290])比BMI<25的患者翻修风险更高(P<0.001)。糖尿病(1.326,95%可信区间[1.242, 1.416],P<0.001)、功能依赖(1.411,95%可信区间[1.183, 1.683],P<0.001)、慢性阻塞性肺疾病(1.315,95%可信区间[1.137, 1.512],P<0.001)、高血压(1.398,95%可信区间[1.330, 1.470],P<0.001)和吸烟(1.082,95%可信区间[1.018, 1.151],P=0.012)与翻修风险增加相关。泊松对数线性回归显示性别(P=19.9,P<0.001)、种族(P=39.5,P<0.001)、糖尿病(P=10.1,P=0.001)、吸烟(P=18.5,P<0.001)、高血压(P=16.4,P<0.001)、年龄(P=102.4,P<0.001)和BMI(P=4.7,P=0.029)是翻修的显著预测因素,使用类固醇(P=3.5,P=0.061)和功能状态(P=3.7,P=0.055)接近显著水平。
结论
患者人口统计学特征、合并症和康复状态可能与腰椎显微椎间盘切除术后椎间盘再次突出和翻修手术率显著相关。我们发现翻修手术的显著预测因素是功能依赖、高龄、男性、白人种族、肥胖、糖尿病、吸烟和高血压。早期识别并关注可改变风险因素将有助于指导初次腰椎显微椎间盘切除术后的患者并改善手术效果。