Guo Lin-Na, Yang Yan-Zong, Feng Yun-Zhi
Department of Stomatology, The Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha, 410011, Hunan, China.
BMC Oral Health. 2018 Apr 10;18(1):63. doi: 10.1186/s12903-018-0524-4.
Iron disorder and abnormal expression of hepcidin play important roles in many diseases, but it is still unclear in chronic periodontitis (CP) and type 2 diabetes mellitus (T2DM). We aimed to assess ferritin and hepcidin levels in serum and saliva of CP patients with or without T2DM.
Serum and unstimulated whole saliva samples were collected from 88 participants, who were categorized into 4 groups based on the presence or absence of CP or T2DM. Demographics and general health parameters were recorded. Full-mouth clinical periodontal parameters including probing pocket depth, clinical attachment loss, bleeding index, and plaque index were recorded. Chemiluminescence microparticle immunoassay and enzyme-linked immunosorbent assay were used to detect ferritin and hepcidin concentrations, respectively, in serum and saliva.
Serum ferritin and hepcidin levels in the CP and CP with T2DM groups were higher than in the control group (P < 0.05). Serum hepcidin and serum ferritin are linear correlated (P < 0.001). Serum hepcidin/ferritin values in the CP with T2DM group were significantly lower than those in the T2DM and control groups. Moreover, salivary ferritin levels in the CP and T2DM groups were higher than those in the control group (P < 0.05). There was positively correlation between salivary ferritin and serum ferritin (P = 0.017). Hepcidin concentrations were relatively low in saliva.
These results suggest that iron overload and hepcidin inadequacy existed in CP with T2DM patients. Salivary ferritin might provide a reference for body iron load.
ChiCTR-ROC-17012780.
铁代谢紊乱和铁调素异常表达在多种疾病中起重要作用，但在慢性牙周炎（CP）和2型糖尿病（T2DM）中仍不清楚。我们旨在评估合并或不合并T2DM的CP患者血清和唾液中的铁蛋白和铁调素水平。
收集了88名参与者的血清和非刺激性全唾液样本，根据是否存在CP或T2DM将其分为4组。记录人口统计学和一般健康参数。记录全口临床牙周参数，包括探诊深度、临床附着丧失、出血指数和菌斑指数。分别采用化学发光微粒子免疫分析法和酶联免疫吸附测定法检测血清和唾液中的铁蛋白和铁调素浓度。
CP组和合并T2DM的CP组血清铁蛋白和铁调素水平高于对照组（P < 0.05）。血清铁调素与血清铁蛋白呈线性相关（P < 0.001）。合并T2DM的CP组血清铁调素/铁蛋白值显著低于T2DM组和对照组。此外，CP组和T2DM组的唾液铁蛋白水平高于对照组（P < 0.05）。唾液铁蛋白与血清铁蛋白呈正相关（P = 0.017）。唾液中铁调素浓度相对较低。
这些结果表明，合并T2DM的CP患者存在铁过载和铁调素不足。唾液铁蛋白可能为机体铁负荷提供参考。
ChiCTR-ROC-17012780。
