Feng Xin-Di, Wang Shao-Feng, Qiao Si-Yu, Huang Jia-Ying, Ma Zi-Lin, Zhou Duan, Tang Jing-Yi, Wei Yi-Hong
Department of Cardiovascular, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
Department of Traditional Chinese Medicine, Chuansha Huaxia Community Health Service Center, Shanghai, People's Republic of China.
Vasc Health Risk Manag. 2025 Apr 7;21:217-228. doi: 10.2147/VHRM.S504454. eCollection 2025.
To analyze the relationship between resistant hypertension (RH) and hypertension, diabetes mellitus, chronic kidney disease, sodium, calcium, magnesium, phosphorus.
A total of 475 patients with hypertension admitted to Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from January 2021 to December 2023 were divided into hypertension group (HT group) and resistant hypertension group (RH group). We compared the differences between these two groups, and analyzed the influencing factors of RH, as well as the correlation between RH and the course of hypertension, diabetes mellitus, chronic kidney disease, and levels of sodium, calcium, magnesium and phosphorus.
Compared with HT group, RH group had a significantly higher blood pressure ( < 0.05), longer duration of hypertension, diabetes mellitus, and chronic kidney disease ( < 0.01) and a higher proportion of combined chronic kidney disease ( = 0.006). The duration of hypertension, serum sodium ion concentration (≥142.00 mmol/L), calcium ion concentration (2.19 to < 2.30 mmol/L), and 24h urinary phosphorus ion level were independent influencing factors of RH ( < 0.05).
For hypertension patients with diabetes mellitus or chronic kidney disease, the risk of RH is significantly higher. The risk of RH may be lower in patients with blood sodium <142.00 mmol/L, blood calcium >2.29 mmol/L, 24h urine sodium and magnesium ions of 116.52 and 2.69 mmol, respectively, and higher 24h urine phosphorus ions.
分析难治性高血压（RH）与高血压、糖尿病、慢性肾脏病、钠、钙、镁、磷之间的关系。
选取2021年1月至2023年12月上海中医药大学附属龙华医院收治的475例高血压患者，分为高血压组（HT组）和难治性高血压组（RH组）。比较两组之间的差异，分析RH的影响因素，以及RH与高血压病程、糖尿病、慢性肾脏病、钠、钙、镁、磷水平的相关性。
与HT组相比，RH组血压显著更高（<0.05），高血压、糖尿病和慢性肾脏病病程更长（<0.01），合并慢性肾脏病的比例更高（=0.006）。高血压病程、血清钠离子浓度（≥142.00 mmol/L）、钙离子浓度（2.19至<2.30 mmol/L）和24小时尿磷离子水平是RH的独立影响因素（<0.05）。
合并糖尿病或慢性肾脏病的高血压患者发生RH的风险显著更高。血钠<142.00 mmol/L、血钙>2.29 mmol/L、24小时尿钠和镁离子分别为116.52和2.69 mmol且24小时尿磷离子更高的患者发生RH的风险可能更低。
