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募集顺序的中枢决定:膈运动神经元的细胞内研究

Central determination of recruitment order: intracellular study of phrenic motoneurons.

作者信息

Monteau R, Khatib M, Hilaire G

出版信息

Neurosci Lett. 1985 May 23;56(3):341-6. doi: 10.1016/0304-3940(85)90266-6.

DOI:10.1016/0304-3940(85)90266-6
PMID:4022446
Abstract

Simultaneous recordings were made intracellularly from phrenic motoneurons (PMs) and extracellularly from their central drivers, the inspiratory bulbospinal neurons (IBSNs) of the dorsal respiratory nucleus. On the basis of their order of recruitment from the beginning of inspiration (as estimated by the phrenic discharge). PMs and IBSNs were classified as early (E) or late (L) units. Unitary excitatory postsynaptic potentials (EPSPs) evoked in the PM by the IBSN were frequently observed between IBSNs and PMs with a similar recruitment, both E, 11/28 or both L, 10/13, and were scarce between IBSNs and PMs with different recruitment. E and L, 8/28, or L and E, 2/11. Since measured membrane resistances of E and L PMs were not statistically different, the recruitment order of PMs may be considered as mainly determined by the timing (E or L) of the central drive that they received.

摘要

同时对膈运动神经元(PMs)进行细胞内记录,并对其位于背侧呼吸核的中枢驱动神经元,即吸气性延髓脊髓神经元(IBSNs)进行细胞外记录。根据从吸气开始时它们被募集的顺序(通过膈放电估计),将PMs和IBSNs分为早期(E)或晚期(L)单位。在具有相似募集顺序的IBSNs和PMs之间,即两者均为E,11/28,或两者均为L,10/13,经常观察到IBSN在PM中诱发的单突触兴奋性突触后电位(EPSPs),而在具有不同募集顺序的IBSNs和PMs之间则很少见,即E和L,8/28,或L和E,2/11。由于测得的E型和L型PMs的膜电阻无统计学差异,PMs的募集顺序可被认为主要由它们所接受的中枢驱动的时间(E或L)决定。

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