Ingemarsson I, Bengtsson B
Obstet Gynecol. 1985 Aug;66(2):176-80.
The medical records of 330 patients treated with terbutaline infusion for the inhibition of preterm labor were reviewed over a five-year period. In patients with intact membranes the results were uniformly good, particularly when treatment was instituted before the 30th week. Half these patients had a prolonged labor of six weeks or more; in most cases of treatment failure complications already existed on admission. In only nine patients (2.7%) terbutaline treatment was stopped due to side effects: predominantly maternal tachycardia or vomiting. Two patients had chest symptoms, but in no case was pulmonary edema diagnosed. The results suggested that a low incidence of severe side effects can be obtained if the following precautions are taken: glucose is used as the infusion medium, instead of sodium chloride; concentrated solutions are given to avoid fluid overload; the patients are carefully controlled; and the infusion is immediately reduced or stopped if signs of severe side effects appear.
对330例接受特布他林静脉输注以抑制早产的患者的病历进行了为期五年的回顾。对于胎膜完整的患者，结果一致良好，尤其是在第30周之前开始治疗时。这些患者中有一半分娩延长了六周或更长时间；在大多数治疗失败的病例中，入院时就已存在并发症。仅9例患者（2.7%）因副作用而停止特布他林治疗：主要是母体心动过速或呕吐。两名患者有胸部症状，但均未诊断出肺水肿。结果表明，如果采取以下预防措施，可以获得较低的严重副作用发生率：使用葡萄糖而非氯化钠作为输注介质；给予浓缩溶液以避免液体过载；对患者进行仔细监测；如果出现严重副作用迹象，立即减少或停止输注。
