Sodagar Abolfazl, Paulino Sujeirys, Javed Nismat, Molina Marcos, Khaja Misbahuddin
Internal Medicine/Pulmonary Critical Care, BronxCare Health System, Bronx, USA.
Internal Medicine, BronxCare Health System, Icahn School of Medicine at Mount Sinai, New York, USA.
Cureus. 2025 Mar 12;17(3):e80471. doi: 10.7759/cureus.80471. eCollection 2025 Mar.
Granular cell tumors (GCTs) are rare soft tissue tumors with a myogenic origin. While GCTs typically arise in the tongue, skin, and subcutaneous tissues, pulmonary involvement (pGCT) remains rare. The most common site in the case of pGCT is the bronchus, followed by the trachea and lung parenchyma. In this case, we discuss the presentation of a 33-year-old female with respiratory distress who was subsequently diagnosed with pGCT, and her dyspnea resolved after conservative management. Bronchoscopic evaluation and biopsy with histopathological examination remain the cornerstone for diagnosis and management. While most pGCTs are benign, a few can be malignant and require additional techniques for management. Given their infrequency, pGCTs can pose diagnostic challenges, often mimicking other endobronchial lesions clinically and radiologically. Management strategies range from conservative observation especially for smaller, asymptomatic tumors to surgical resection or bronchoscopic excision for those exhibiting significant symptoms, airway compromise, or features suggestive of malignancy.
颗粒细胞瘤（GCTs）是一种起源于肌源性的罕见软组织肿瘤。虽然GCTs通常发生于舌、皮肤和皮下组织，但肺部受累（pGCT）仍然罕见。pGCT最常见的部位是支气管，其次是气管和肺实质。在此病例中，我们讨论了一名33岁出现呼吸窘迫的女性，随后被诊断为pGCT，经保守治疗后其呼吸困难得到缓解。支气管镜评估及活检并进行组织病理学检查仍是诊断和治疗的基石。虽然大多数pGCT是良性的，但少数可能是恶性的，需要采用其他技术进行治疗。鉴于其罕见性，pGCT可能带来诊断挑战，在临床和放射学上常与其他支气管内病变相似。治疗策略从保守观察（特别是对于较小的无症状肿瘤）到手术切除或支气管镜切除（对于那些出现明显症状、气道受压或提示恶性特征的肿瘤）不等。
