Wu Ling-Yi, Yang Tsao-Chin, Kuo Shi-Wen, Hsiao Chin-Fu, Hung Yi-Jen, Hsieh Chang-Hsun, Tseng He-Chih, Hsieh An-Tsz, Chen Teng-Wei, Chang Jin-Biou, Pei Dee
Department of Internal Medicine, Tri-Service General Hospital, Neihu, Taipei, Taiwan, ROC.
Endocr Res. 2003 Aug;29(3):317-25. doi: 10.1081/erc-120025039.
Many studies showed that depression is correlated with osteoporosis, while others showed that low cholesterol level is also related to depression. However, these relationships still remain controversial. Since the bone mineral density (BMD) is related to depression and depression is related to hypocholesterolemia, there might exist a correlation between BMD and plasma cholesterol levels. To prove this, we enrolled 5000 individuals, 2170 males, and 2830 females, who had health check-ups at a private clinic between 1998 and 1999. They were divided into three groups. Group 1 was composed of male subjects; Group 2, female subjects; and Group 3, females aged over 50 to exclude pre-menopausal females. Each subject had a routine physical examination, fasting blood drawing, BMD measured by dual energy x-ray absorptiometry (DEXA) over the wrist, and was given a questionnaire to answer. Between Groups 1 and 2, the females were significantly younger, had higher body mass index (BMI), total cholesterol (TC), high density lipoprotein cholesterol (HDLC), low density lipoprotein cholesterol (LDLC), and platelet, but lower BMD, fasting plasma glucose (FPG), triglycerides (TG), hemoglobin (Hgb), and white blood cell (WBC) count. As for Groups 1 and 3, all the aforementioned findings still remained the same except that the systolic blood pressure (SBP) was higher and diastolic blood pressure (DBP) was lower in Group 3. Our results showed that BMD is negatively related to age in males. In females, it is negatively correlated with age, FPG, PPG, SBP, DBP, TC, LDLC, TG, and Hgb, but positively related to BMI and platelet. However, for females in Group 3, BMD is only negatively related to age, FPG, SBP, and TG but positively related to BMI. Stepwise multiple regression analysis showed that the BMD is negatively related to age but positively related to BMI in both males and females. In Group 3, BMD is negatively related to age and FPG but positively related BMI. In conclusion, no correlation exists between BMD and cholesterol. This implies that the depression is not significantly related to cholesterol and/or BMD. This might be due to various confounding factors, which could affect their relationships. The negative correlation between BMD and FPG is only observed in females older than 50 years. Further studies are needed to clarify these relationships.
许多研究表明抑郁症与骨质疏松症相关，而其他研究则表明低胆固醇水平也与抑郁症有关。然而，这些关系仍存在争议。由于骨矿物质密度（BMD）与抑郁症相关，且抑郁症与低胆固醇血症相关，因此BMD与血浆胆固醇水平之间可能存在关联。为了证实这一点，我们招募了5000名个体，其中男性2170名，女性2830名，他们于1998年至1999年期间在一家私人诊所进行了健康检查。他们被分为三组。第一组由男性受试者组成；第二组为女性受试者；第三组为50岁以上的女性，以排除绝经前女性。每位受试者都进行了常规体检、空腹抽血、通过双能X线吸收法（DEXA）测量手腕部的BMD，并填写了一份问卷。在第一组和第二组之间，女性明显更年轻，体重指数（BMI）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDLC）、低密度脂蛋白胆固醇（LDLC）和血小板更高，但BMD、空腹血糖（FPG）、甘油三酯（TG）、血红蛋白（Hgb）和白细胞（WBC）计数更低。至于第一组和第三组，除了第三组的收缩压（SBP）更高、舒张压（DBP）更低外，所有上述结果仍然相同。我们的结果表明，男性的BMD与年龄呈负相关。在女性中，它与年龄、FPG、PPG、SBP、DBP、TC、LDLC、TG和Hgb呈负相关，但与BMI和血小板呈正相关。然而，对于第三组中的女性，BMD仅与年龄、FPG、SBP和TG呈负相关，但与BMI呈正相关。逐步多元回归分析表明，男性和女性的BMD均与年龄呈负相关，但与BMI呈正相关。在第三组中，BMD与年龄和FPG呈负相关，但与BMI呈正相关。总之，BMD与胆固醇之间不存在关联。这意味着抑郁症与胆固醇和/或BMD没有显著关系。这可能是由于各种混杂因素影响了它们之间的关系。BMD与FPG之间的负相关仅在50岁以上的女性中观察到。需要进一步研究来阐明这些关系。
