Wilar Gofarana, Suhandi Cecep, Fukunaga Kohji, Shigeno Masanori, Kawahata Ichiro, Abdulah Rizky, Sasaki Takuya
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, Indonesia.
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, Indonesia; Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, Indonesia.
Pharmacol Res. 2025 Mar;213:107641. doi: 10.1016/j.phrs.2025.107641. Epub 2025 Feb 1.
Metabolic syndrome (MetS) encompasses metabolic risk factors like elevated blood glucose, abnormal lipid levels, and hypertension. Nanocurcumin, a nanoscale formulation of curcumin, may offer therapeutic benefits for MetS management. This systematic review and meta-analysis evaluates the impact of nanocurcumin supplementation on key MetS parameters.
A systematic literature search identified 20 randomized controlled trials (RCTs) with 1394 participants. Data were pooled using a random-effects model, and standardized mean differences (SMDs) were calculated for key outcomes.
Nanocurcumin supplementation significantly improved waist circumference (WC) (standardized mean difference (SMD): -0.30 cm), fasting blood sugar (FBS) (SMD: -0.34 mg/dL), HbA1c (SMD: -0.33 %), and quantitative insulin sensitivity check index (QUICKI) score (SMD: 0.73). Lipid profile parameters, including total cholesterol (SMD: -0.18 mg/dL), LDL-C (SMD: -0.16 mg/dL), and HDL-C (SMD: 0.32 mg/dL), also reduced significantly. Improvement in diastolic blood pressure (DBP) (SMD: -0.32 mmHg), total antioxidant capacity (TAC) (SMD: 0.44 mmol/L), malondialdehyde (MDA) (SMD: -0.37 mmol/L), tumor necrosis factor-α (TNF-α) (SMD: -2.30 ng/L), interleukin-6 (IL-6) (SMD: -1.07 ng/L), and high-sensitivity C-reactive protein (hs-CRP) (SMD: -0.34 mg/L) were observed.
Nanocurcumin supplementation significantly improves multiple MetS-related parameters, including anthropometric measures, glycemic control, lipid profile, blood pressure, oxidative stress markers, and inflammatory biomarkers. These findings highlight nanocurcumin's potential as an effective adjunctive therapy for managing MetS. However, the variability in study participant ages, treatment durations, and sample sizes suggests the need for further well-designed RCTs to establish optimal usage guidelines.
代谢综合征（MetS）包含血糖升高、血脂异常和高血压等代谢风险因素。纳米姜黄素是姜黄素的纳米级制剂，可能对代谢综合征的管理具有治疗益处。本系统评价和荟萃分析评估了补充纳米姜黄素对代谢综合征关键参数的影响。
系统的文献检索确定了20项随机对照试验（RCT），涉及1394名参与者。使用随机效应模型汇总数据，并计算关键结局的标准化均数差（SMD）。
补充纳米姜黄素显著改善了腰围（WC）（标准化均数差（SMD）：-0.30厘米）、空腹血糖（FBS）（SMD：-0.34毫克/分升）、糖化血红蛋白（HbA1c）（SMD：-0.33%）和定量胰岛素敏感性检查指数（QUICKI）评分（SMD：0.73）。血脂谱参数，包括总胆固醇（SMD：-0.18毫克/分升）、低密度脂蛋白胆固醇（LDL-C）（SMD：-0.16毫克/分升）和高密度脂蛋白胆固醇（HDL-C）（SMD：0.32毫克/分升）也显著降低。舒张压（DBP）（SMD：-0.32毫米汞柱）、总抗氧化能力（TAC）（SMD：0.44毫摩尔/升）、丙二醛（MDA）（SMD：-0.37毫摩尔/升）、肿瘤坏死因子-α（TNF-α）（SMD：-2.30纳克/升）、白细胞介素-6（IL-6）（SMD：-1.07纳克/升）和高敏C反应蛋白（hs-CRP）（SMD：-0.34毫克/升）均有改善。
补充纳米姜黄素显著改善了多个与代谢综合征相关的参数，包括人体测量指标、血糖控制、血脂谱、血压、氧化应激标志物和炎症生物标志物。这些发现凸显了纳米姜黄素作为代谢综合征有效辅助治疗手段的潜力。然而，研究参与者年龄、治疗持续时间和样本量的差异表明，需要进一步设计良好的随机对照试验来制定最佳使用指南。
