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供体动脉斑块中差异表达的基因和蛋白质对同种异体肾移植后肾功能恢复的影响。

Impact of differentially expressed genes and proteins in donor arterial plaque on renal function recovery following allogeneic kidney transplantation.

作者信息

Tian Zijian, Tang Yongbin, Wang Jinfu, Zhang Zhipeng, Meng Lingfeng, Zhang Hong, Zhang Yaqun

机构信息

Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China.

Department of Urology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.

出版信息

Transl Androl Urol. 2025 Mar 30;14(3):637-650. doi: 10.21037/tau-2024-736. Epub 2025 Mar 26.

DOI:10.21037/tau-2024-736
PMID:40226083
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11986501/
Abstract

BACKGROUND

Donor kidney arteriosclerotic plaque is a risk factor for renal allograft functional injury. The aim of this study was to screen, identify, and verify differentially expressed genes (DEGs) and proteins in arteriosclerotic plaques and analyze their correlation with renal transplant function recovery.

METHODS

This study included 82 deceased donor allogeneic kidney transplant recipients and analyzed 20 eligible donor arterial plaque specimens. Patients were divided into "no or mild" and "moderate or severe" donor arteriosclerotic plaque groups. The latter group was further divided into impaired and normal kidney function groups. Correlations between target DEGs and proteins and transplanted kidney function recovery were determined using immunofluorescence assay, polymerase chain reaction (PCR), and western blotting.

RESULTS

We identified 40 intersecting DEGs. Matrix metallopeptidase 12 () and aquaporin 9 () were identified as target DEGs, with their expression found to be higher in the "moderate or severe" group compared with that in the "no or mild" group. Additionally, and expression was higher in the impaired group than it was in the normal kidney function group. and are associated with transplanted kidney function recovery.

CONCLUSIONS

Our study contributes valuable information to the development of clinical strategies for kidney transplant maintenance.

摘要

背景

供体肾动脉粥样硬化斑块是同种异体肾移植功能损伤的一个危险因素。本研究的目的是筛选、鉴定和验证动脉粥样硬化斑块中差异表达基因（DEGs）和蛋白质，并分析它们与肾移植功能恢复的相关性。

方法

本研究纳入了82例脑死亡供体同种异体肾移植受者，并分析了20份合格的供体动脉斑块标本。患者被分为“无或轻度”和“中度或重度”供体动脉粥样硬化斑块组。后一组又进一步分为肾功能受损组和肾功能正常组。使用免疫荧光测定、聚合酶链反应（PCR）和蛋白质免疫印迹法确定目标DEGs和蛋白质与移植肾功能恢复之间的相关性。

结果

我们鉴定出40个交集DEGs。基质金属肽酶12（）和水通道蛋白9（）被鉴定为目标DEGs，发现它们在“中度或重度”组中的表达高于“无或轻度”组。此外，在肾功能受损组中的表达高于肾功能正常组。和与移植肾功能恢复相关。

结论

我们的研究为肾移植维持临床策略的制定提供了有价值的信息。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56d3/11986501/c60440c19aa5/tau-14-03-637-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56d3/11986501/d68b65924c9f/tau-14-03-637-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56d3/11986501/d8fa670e15ff/tau-14-03-637-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56d3/11986501/0e87b99df34b/tau-14-03-637-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56d3/11986501/631cc775da68/tau-14-03-637-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56d3/11986501/c0cfd729a740/tau-14-03-637-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56d3/11986501/d1507ce3321a/tau-14-03-637-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56d3/11986501/c60440c19aa5/tau-14-03-637-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56d3/11986501/d68b65924c9f/tau-14-03-637-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56d3/11986501/d8fa670e15ff/tau-14-03-637-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56d3/11986501/0e87b99df34b/tau-14-03-637-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56d3/11986501/631cc775da68/tau-14-03-637-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56d3/11986501/c0cfd729a740/tau-14-03-637-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56d3/11986501/d1507ce3321a/tau-14-03-637-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56d3/11986501/c60440c19aa5/tau-14-03-637-f7.jpg

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Cardiovasc Diabetol. 2023 Nov 28;22(1):327. doi: 10.1186/s12933-023-02064-3.
2
Integration of machine learning to identify diagnostic genes in leukocytes for acute myocardial infarction patients.将机器学习整合到白细胞中，以识别急性心肌梗死患者的诊断基因。
J Transl Med. 2023 Oct 27;21(1):761. doi: 10.1186/s12967-023-04573-x.
3
miR-330-3p alleviates the progression of atherosclerosis by downregulating AQP9.
miR-330-3p 通过下调 AQP9 缓解动脉粥样硬化的进展。
Funct Integr Genomics. 2023 Mar 7;23(2):77. doi: 10.1007/s10142-023-01001-7.
4
Survival Benefit of First Single-Organ Deceased Donor Kidney Transplantation Compared With Long-term Dialysis Across Ages in Transplant-Eligible Patients With Kidney Failure.在适合移植的肾衰竭患者中，与长期透析相比，首次单器官已故供体肾移植在各年龄段的生存获益。
JAMA Netw Open. 2022 Oct 3;5(10):e2234971. doi: 10.1001/jamanetworkopen.2022.34971.
5
The Independent Effects of Procurement Biopsy Findings on 10-Year Outcomes of Extended Criteria Donor Kidney Transplants.获取性活检结果对扩大标准供体肾移植10年预后的独立影响
Kidney Int Rep. 2022 May 30;7(8):1850-1865. doi: 10.1016/j.ekir.2022.05.027. eCollection 2022 Aug.
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