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孕期发生的一例罕见的垂体细胞瘤病例。

A Rare Case of Pituicytoma During Pregnancy.

作者信息

Wu Junchen, Tang Hao, Zhang Bo, Lin Shaojian, Wu Zhe Bao

机构信息

Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai 200001, China.

出版信息

JCEM Case Rep. 2025 Apr 11;3(5):luaf071. doi: 10.1210/jcemcr/luaf071. eCollection 2025 May.

Abstract

Pituicytomas are rare benign sellar tumors that originate in the neurohypophysis. We report the first case of a pituicytoma during pregnancy, causing headaches and bilateral temporal visual field defects. A 32-year-old woman at 16 weeks of gestation was admitted to our hospital for headaches and progressively worsening visual impairment. Cranial magnetic resonance imaging (MRI) revealed a sellar lesion that was resected via a neuroendoscopic endonasal-transsphenoid approach. Pathology revealed a pituicytoma with positive progesterone receptor expression. After cerebrospinal fluid (CSF) leakage repair and anti-infective therapy, the patient recovered well and finally gave birth to a healthy child. This is the first case of pituicytoma during pregnancy reported. Pregnancy may have a contributing effect on the progression of progesterone receptor-positive pituicytomas. Surgical intervention, when performed with appropriate perioperative management, can effectively alleviate mass effects caused by pituicytomas in pregnant women while maintaining the safety of the fetus.

摘要

垂体细胞瘤是起源于神经垂体的罕见良性鞍区肿瘤。我们报告了首例孕期垂体细胞瘤病例,该病例导致头痛和双侧颞侧视野缺损。一名孕16周的32岁女性因头痛和视力进行性恶化入住我院。头颅磁共振成像(MRI)显示鞍区有一病变,通过神经内镜鼻内 - 经蝶窦入路进行了切除。病理显示为孕激素受体表达阳性的垂体细胞瘤。经过脑脊液(CSF)漏修补和抗感染治疗,患者恢复良好,最终产下一名健康婴儿。这是首例报道的孕期垂体细胞瘤病例。妊娠可能对孕激素受体阳性的垂体细胞瘤进展有促进作用。在进行适当的围手术期管理时,手术干预可有效缓解孕妇垂体细胞瘤引起的占位效应,同时维持胎儿安全。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8cf/11986585/89e91996631d/luaf071f1.jpg

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