Matias Susana L, French Caitlin D, Saavedra Jessica, Shankar Akshara, Rymland Aidan S, Rodriguez Beltran Ivan, Collado Jose O, Waterman Carrie
Department of Nutritional Sciences & Toxicology, University of California, Berkeley, CA, USA.
Department of Nutrition, University of California, Davis, CA, USA.
Prev Med Rep. 2025 Mar 24;53:103048. doi: 10.1016/j.pmedr.2025.103048. eCollection 2025 May.
To assess the acceptability of moringa leaf powder, a nutrient-dense plant that has been mostly tested in pre-clinical studies.
We conducted an acceptability study of different doses of moringa leaf powder in California in 2023. Participants were randomly assigned to one of the three groups (one tsp. ≈ 2.4 g [low dose], two tsp. ≈ 4.8 g [medium dose], or three tsp. ≈ 7.2 g [high dose]) and instructed to consume the moringa powder with foods or beverages for seven days. Participants were interviewed and had their skin carotenoid levels measured at baseline and endline and completed daily surveys on consumption and side effects. The study outcomes were consumption (number of days it was consumed), liking (sum of organoleptic characteristics ratings) and side effects (number of symptoms reported).
Fifty-two participants were enrolled; 96 % completed the study. The number of days that moringa was consumed (Median = 7, Interquartile range:7,7), changes in skin carotenoid levels, and total liking scores did not differ by dose group ( = 0.56, = 0.79, and = 0.27, respectively). The number of overall and gastrointestinal (GI) symptoms differed by dose group. Participants in the high dose group self-reported more overall ( = 0.001) and GI symptoms ( = 0.002) than those in the low dose group.
Compliance in consuming moringa was high for all groups, suggesting that all three doses tested may be acceptable in future moringa supplementation trials. GI symptoms may occur more frequently when the moringa doses are higher than 7 g/day, but they tend to be mild and transient.
评估辣木叶粉的可接受性,辣木叶粉是一种营养丰富的植物,此前大多在临床前研究中进行过测试。
2023年,我们在加利福尼亚州开展了一项关于不同剂量辣木叶粉可接受性的研究。参与者被随机分配到三组中的一组(一茶匙≈2.4克[低剂量]、两茶匙≈4.8克[中剂量]或三茶匙≈7.2克[高剂量]),并被要求连续七天将辣木粉与食物或饮料一起食用。在基线期和结束期对参与者进行访谈并测量其皮肤类胡萝卜素水平,参与者还需完成关于食用情况和副作用的每日调查。研究结果包括食用天数(食用的天数)、喜爱程度(感官特征评分总和)和副作用(报告的症状数量)。
共招募了52名参与者;96%完成了研究。辣木的食用天数(中位数=7,四分位间距:7,7)、皮肤类胡萝卜素水平的变化以及总喜爱得分在不同剂量组之间没有差异(分别为=0.56、=0.79和=0.27)。总体症状和胃肠道(GI)症状的数量在不同剂量组之间存在差异。高剂量组的参与者自我报告的总体症状(=0.001)和GI症状(=0.002)比低剂量组更多。
所有组食用辣木的依从性都很高,这表明在未来的辣木补充剂试验中,所测试的三种剂量可能都是可接受的。当辣木剂量高于7克/天时,GI症状可能更频繁出现,但往往较为轻微且短暂。