基于反射光谱法评估的皮肤类胡萝卜素对种族/民族多样化样本中 6 周随机对照喂养试验中类胡萝卜素摄入量变化敏感。
Reflection Spectroscopy-Assessed Skin Carotenoids Are Sensitive to Change in Carotenoid Intake in a 6-Week Randomized Controlled Feeding Trial in a Racially/Ethnically Diverse Sample.
机构信息
East Carolina University Department of Public Health, Greenville, NC, USA.
Baylor College of Medicine, Houston, TX, USA.
出版信息
J Nutr. 2023 Apr;153(4):1133-1142. doi: 10.1016/j.tjnut.2023.02.017. Epub 2023 Feb 18.
BACKGROUND
Reflection spectroscopy, utilized by the Veggie Meter, is a less-expensive, noninvasive method to quantify skin carotenoids and is a valid approximation of fruit and vegetable (FV) intake. However, it is unknown to what degree Veggie Meter-assessed skin carotenoid score change is responsive to changes in carotenoid intake.
OBJECTIVES
This study aimed to evaluate Veggie Meter-assessed skin carotenoid score response in a 6-wk randomized controlled trial of a carotenoid-containing juice to determine whether the Veggie Meter can be used to detect nutritionally relevant changes in carotenoid intake; and to compare skin and plasma carotenoid responses with the 6-wk trial.
METHODS
In this 6-wk trial, participants (n = 162) who self-identified as one of 4 US racial/ethnic groups (25% Black, 25% Asian, 27% non-Hispanic White, 23% Hispanic) were randomized to a control group, receiving negligible carotenoids (177 mL apple juice/d), moderate-dose group, receiving 4 mg total carotenoids/d (177 mL orange-carrot juice/d), or high-dose group, receiving 8 mg total carotenoids/d (355 mL orange-carrot juice/d). Skin carotenoid score and plasma total carotenoid concentrations (α-carotene, β-carotene, β-cryptoxanthin, lycopene, lutein, zeaxanthin) were assessed at baseline, 3 wk, and 6 wk (n = 158 completed the trial). Repeated measures linear models were used to examine skin and plasma carotenoids over time and between groups.
RESULTS
At 6 wk, participants in the high-dose and moderate-dose groups had significantly higher mean skin carotenoid scores [414.0 (SD = 100.6) and 369.7 (SD = 100.3), respectively] compared with those in the control group [305.2 (100.5)]. In the high-dose group, there was a 42% change in skin carotenoids from baseline (mean = 290.4) to a 6-wk follow-up (increase of 123, 123/290 = 42.4%). There was a 61% change in the plasma carotenoids in the high-dose group.
CONCLUSIONS
The Veggie Meter is sensitive to increases in daily carotenoid intake in diverse racial/ethnic groups over 6 wk.
CLINICAL TRIALS REGISTRY NUMBER
This trial was registered at clinicaltrials.gov as ID: NCT04056624. Study URL: https://clinicaltrials.gov/ct2/show/NCT04056624.
背景
反射光谱学被 Veggie Meter 采用，是一种廉价、非侵入性的方法，用于量化皮肤类胡萝卜素，并且是水果和蔬菜（FV）摄入量的有效近似值。然而，Veggie Meter 评估的皮肤类胡萝卜素评分变化对类胡萝卜素摄入量变化的反应程度尚不清楚。
目的
本研究旨在评估含有类胡萝卜素的果汁 6 周随机对照试验中 Veggie Meter 评估的皮肤类胡萝卜素评分的反应，以确定 Veggie Meter 是否可用于检测营养相关的类胡萝卜素摄入量变化；并与 6 周试验比较皮肤和血浆类胡萝卜素反应。
方法
在这项 6 周的试验中，自认为属于 4 个美国种族/民族群体之一的参与者（25%黑人，25%亚洲人，27%非西班牙裔白人，23%西班牙裔）被随机分为对照组，接受低剂量类胡萝卜素（177 毫升苹果汁/天）；中剂量组，每天摄入 4 毫克总类胡萝卜素（177 毫升橙胡萝卜汁/天）；高剂量组，每天摄入 8 毫克总类胡萝卜素（355 毫升橙胡萝卜汁/天）。在基线、3 周和 6 周时评估皮肤类胡萝卜素评分和血浆总类胡萝卜素浓度（α-胡萝卜素、β-胡萝卜素、β-隐黄质、番茄红素、叶黄素、玉米黄质）（n=158 完成了试验）。使用重复测量线性模型来检查皮肤和血浆类胡萝卜素随时间的变化和组间差异。
结果
在 6 周时，高剂量组和中剂量组参与者的平均皮肤类胡萝卜素评分[分别为 414.0（SD=100.6）和 369.7（SD=100.3）]明显高于对照组[305.2（SD=100.5）]。在高剂量组，皮肤类胡萝卜素从基线（平均=290.4）到 6 周随访（增加 123，123/290=42.4%）的变化率为 42%。高剂量组的血浆类胡萝卜素变化率为 61%。
结论
在 6 周内，Veggie Meter 对不同种族/民族群体日常类胡萝卜素摄入量的增加敏感。
临床试验注册号
本试验在 clinicaltrials.gov 上注册为 ID：NCT04056624。试验网址：https://clinicaltrials.gov/ct2/show/NCT04056624。
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